Role of a comprehensive pregravid preparation program for obese women in the prevention of gestational complications
- Authors: Makarova E.L1, Olina A.A2, Terekhina N.A3
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Affiliations:
- City Perinatal Center, M.A. Tverie City Hospital
- D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
- Academician E.A. Vagner Perm State Medical University, Ministry of Health of Russia
- Issue: No 4 (2020)
- Pages: 182-189
- Section: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248962
- DOI: https://doi.org/10.18565/aig.2020.4.182-188
- ID: 248962
Cite item
Abstract
Objective. To determine the effectiveness of a comprehensive pregravid preparation program on the basis of studying the features of the course of pregnancy in obese women. Subjects and methods. Examinations were made in 118 reproductive-aged women who were permanent residents in the city of Perm. A study group consisted of 36 patients who underwent a comprehensive pregnancy preparation program (diet therapy, replenishment of macro- and micronutrients: vitamin D, folic acid, iodine, iron, and an anti-obesity drug combination of sibutramine + metformin). Comparison and control groups included women who were unprepared for pregnancy: the comparison group comprised 62 obese patients; the control group consisted of 20 non-obese women. Results. The study group showed an 8.3% weight loss. No reproductive losses were recorded in this group. It was established that threatened miscarriage was diagnosed in 10/32 (34.4%) patients who had received no pregravid preparation and in 7/36 (19.4%) women of the study group. During pregnancy, gestational diabetes mellitus developed in 16/32 (50%) women of the comparison group and in 4/36 (11.1%) women of the study group. Placental insufficiency was detected in 8/36 (22.2%) patients who had received pregravid preparation and in 20/32 (62.6%) who had not. Conclusion. The program proposed by the authors for pregravid preparation with the anti-obesity combination medication Reduxin Forte (especially for women with visceral abdominal obesity), vitamin D3, iodine, and folic acid and their recommendations for lifestyle modification significantly prevent gestational complications.
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About the authors
E. L Makarova
City Perinatal Center, M.A. Tverie City Hospital
Email: makarova803@mail.ru
Cand. Med. Sci. 2, Ignatyev Brothers St., Perm 614600, Russia
A. A Olina
D.O. Ott Research Institute of Obstetrics, Gynecology, and Reproductology
Email: olina29@mail.ru
MD; Professor, Deputy Director of Development 3, Mendeleevskaya Line, Saint Petersburg 199034, Russia
N. A Terekhina
Academician E.A. Vagner Perm State Medical University, Ministry of Health of Russia
Email: terekhina@list.ru
MD; Professor, Head, Department of Biochemistry 28, Petropavlovskaya St., Perm 614990, Russia
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