Algorithm for diagnosis and treatment of gastroesophageal reflux disease in pregnant women

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Abstract

Gastroesophageal reflux disease is a chronic recurrent disorder caused by an impairment of the motor-evacuation function of the organs of the gastroesophageal zone and characterized by regularly repeated reflux of the stomach contents into the esophagus, and sometimes the duodenum. This disease leads to the appearance of clinical symptoms that worsen the quality of life of patients: damage to the mucous membrane of the distal part of the esophagus, dystrophic changes in non-keratinized stratified squamous epithelium, catarrhal or erosive/ulcerative esophagitis (reflux esophagitis), and columnar cell metaplasia in some patients. The article presents the modern data on epidemiology, etiology, pathogenesis, risk factors, clinical picture, diagnosis, and management of pregnant women with gastroesophageal reflux disease in the outpatient and inpatient environment. Particular attention is paid to the principles, methods and choice of medications for the treatment and prevention of this pathology.

Conclusion: The effectiveness of the treatment of gastroesophageal reflux disease with Gaviscon Forte has been found to reach 80–90%. The prognosis for pregnancy and childbirth with timely treatment is favorable. The algorithm for the management of pregnant women with gastroesophageal reflux disease is presented.

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About the authors

Victor L. Tyutyunnik

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Author for correspondence.
Email: tioutiounnik@mail.ru
ORCID iD: 0000-0002-5830-5099

Professor, MD, PhD, Leading Researcher of Research and Development Service

Russian Federation, Moscow

Natalia E. Kan

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
ORCID iD: 0000-0001-5087-5946

Professor, MD, PhD, Deputy Director of Science

Russian Federation, Moscow

Olga I. Mikhailova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: omikhaylova@gmail.com
ORCID iD: 0000-0001-7569-8704

PhD, Researcher, 2nd Maternity Department

Russian Federation, Moscow

Dzhamilia D. Mirzabekova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: Jamilya1705@yandex.ru
ORCID iD: 0000-0002-2391-3334

graduate student

Russian Federation, Moscow

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