Features of the composition of peripheral blood lymphocyte subpopulations with cytotoxic, killer, and regulatory functions in women with recurrent implantation failures in ART programs
- Авторлар: Amyan T.S.1, Krechetova L.V.1, Perminova S.G.1, Vtorushina V.V.1
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Мекемелер:
- Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
- Шығарылым: № 12 (2017)
- Беттер: 78-83
- Бөлім: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/248068
- DOI: https://doi.org/10.18565/aig.2017.12.78-83
- ID: 248068
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective. To analyze the content of peripheral blood lymphocyte subpopulations with cytotoxic, killer, and regulatory functions in female patients with recurrent implantation failures in assisted reproductive technology programs. Subjects and methods. The investigation enrolled 48 patients with recurrent implantation failures in an IVF program and 26 fertile women with their last child aged less than 2 years. Results. There was a reduction in T lymphocytes (CD3+) and T lymphocytes with cytotoxic function (CD3+CD8+) and an increase in innate immunity cells with both cytotoxic (CD3-CD8+) and killer (CD56+, CD16+, CD56,16+) functions. The group patients showed a significant rise in gd+Т cell levels in a cryo-cycle (p = 0.005). Conclusion. In patients with recurrent implantation failures, the composition of lymphocyte subpopulations is characterized by a decrease in T lymphocytes (CD3+) and Tlymphocytes with cytotoxic function (CD3+CD8+) and by an increase in innate immunity cells with both cytotoxic and killer functions.
Толық мәтін
Авторлар туралы
Tatiana Amyan
Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
Email: amyantanya@rambler.ru
a graduate student of the 1st year of study department of conservation and restoration of reproductive function
Lubov Krechetova
Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
Email: k_l_v_@mail.ru
PhD, Senior Research Fellow, Head of the Laboratory Laboratory of Clinical Immunology
Svetlana Perminova
Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
Email: perisvet@list.ru
MD, a leading researcher department of conservation and restoration of reproductive function
Valentina Vtorushina
Research Center of Obstetrics, Gynecology and Perinatology named after V.I. Kulakov
Email: vtorushina@inbox.ru
PhD, doctor of clinical laboratory diagnostics
Әдебиет тізімі
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