On prospects for using combinations of folic acid and active folates for the nutritional support of pregnancy


Дәйексөз келтіру

Толық мәтін

Ашық рұқсат Ашық рұқсат
Рұқсат жабық Рұқсат берілді
Рұқсат жабық Рұқсат ақылы немесе тек жазылушылар үшін

Аннотация

Folic acid is most often used for the primary prevention of fetal malformations (FMFs). The prevention of FMFs and pregnancy pathologies with folates in a synergistic combination with other vitamins is very effective due to the widespread distribution of polyhypovitaminoses. Folic acid bioavailability substantially depends on the dose used and the genetic profile of a patient, so the promising trend is to use active folate forms (for example, 5-methyltetrahydrofolate (5-MTHF)). In this case, 5-MTHP can be used in combination with folic acid, since this provides an obvious pharmacokinetic advantage of maintaining more stable blood folate levels. If the dosage of folic acid in such combinations does not exceed 400 ig/day, folic acid will not lead to impaired metabolism of endogenous folates, including 5-MTHF.

Толық мәтін

Рұқсат жабық

Авторлар туралы

Olga Gromova

Federal Research Center of Informatics and Management, Russian Academy of Sciences

Email: unesco.gromova@gmail.com
MD, professor, science head of the Institute of Pharmacoinformatics, leading researcher of the Department of Intellectual Systems, Institute of Pharmacoinformatics

Ivan Torshin

Federal Research Center of Informatics and Management, Russian Academy of Sciences

PhD in Applied Mathematics, senior researcher, Institute of Pharmacoinformatics

Nana Tetruashvili

Academician V.I. Kulakov National Medical Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation

Email: n_tetruashvili@oparina4.ru
MD, head of the Department of Pregnancy Loss Prevention and Therapy

Anna Galustyan

Saint Petersburg State Pedagogical Medical University

Email: klinika.spb@gmail.com
PhD, associate professor, head of the Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics

Natalia Kuritsyna

Saint Petersburg State Pedagogical Medical University

Email: klinika.spb@gmail.com
PhD, associate professor, Department of Pharmacology with a course of clinical pharmacology and pharmacoeconomics

Әдебиет тізімі

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