The practice of prescribing antimicrobials to pregnant women with concomitant somatic diseases

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Background: Clinical and pharmacoepidemiological studies have been conducted to optimize the use of antibacterial drugs in pregnant women with somatic diseases.

Objective: To analyze the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases in routine medical practice.

Materials and methods: A non-interventional retrospective analysis of data from different forms of primary medical documentation was carried out in 144 pregnant women who received systemic antimicrobial therapy for somatic diseases.

Results: The investigation revealed the irrational use of antimicrobial drugs in pregnant women with concomitant somatic diseases: the prescription of identical antibiotics for somatic diseases and peripartum infections; the unreasonable use of preventive cycles of antibacterial drugs, the excessive use of restricted antibiotics according to the WHO AWaRe classification database (third-generation cephalosporins) and inhibitor-protected β-lactam agents.

Conclusion: To date, the prescription of systemic antimicrobial drugs to pregnant women with concomitant somatic diseases is rational only in 68.2% of cases.

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作者简介

Nikolay Korobkov

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0001-7279-2535
SPIN 代码: 4191-3581

PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology

俄罗斯联邦, Saint Petersburg

Natalia Bakulina

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-4075-4096
SPIN 代码: 9503-8950

Dr. Med. Sci., Professor, Head of the Department of Internal Medicine, Clinical Pharmacology and Nephrology, Vice-Rector for Science and Innovation

俄罗斯联邦, Saint Petersburg

Margarita Repina

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru

Dr. Med. Sci., Professor

俄罗斯联邦, Saint Petersburg

Olga Arnt

I.I. Mechnikov North-Western State Medical University, Ministry of Health of Russia

Email: nikolai_korobkov@mail.ru
ORCID iD: 0000-0003-1565-2012
SPIN 代码: 1482-0917

PhD, Associate Professor at the S.N. Davydov Department of Obstetrics and Gynecology

俄罗斯联邦, Saint Petersburg

参考

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  12. WHO model list of essential medicines. 20th list (March 2017) Geneva: World Health Organization; 2017. Available at: www.who.int/publications/i/item/2021-aware-classification (Accessed 03.01.2023).
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补充文件

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1. JATS XML
2. Figure 1. Structure of antimicrobial chemotherapy for urinary tract infections in pregnant women (n=98), %

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3. Figure 2. Bacteriological structure of urinary tract infections during pregnancy (n=80), %

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4. Figure 3. The total frequency of insensitivity of isolated bacterial pathogens to the main antimicrobial drugs used in the treatment of urinary tract infections in pregnant women, %

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5. Figure 4. Structure of antimicrobial chemotherapy for respiratory infections in pregnant women (n=43), %

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6. Figure 5. Bacteriological structure of respiratory infections in pregnant women (n=43), %

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