Complex therapy of recurrent vulvovaginal candidiasis in pregnancy
- Авторлар: Tyutyunnik V.L.1, Kan N.E.1, Tezikov Y.V.2, Lipatov I.S.2, Mikhailova O.I.1, Mirzabekova D.D.1
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Мекемелер:
- Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Samara State Medical University, Ministry of Health of Russia
- Шығарылым: № 11 (2023)
- Беттер: 150-156
- Бөлім: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/626136
- DOI: https://doi.org/10.18565/aig.2023.259
- ID: 626136
Дәйексөз келтіру
Ашық рұқсат
Рұқсат берілді
Аннотация
Objective: To analyze the clinical efficacy of combined therapy of vulvovaginal candidiasis in pregnancy.
Materials and methods: The study included 40 women who were pregnant from 13 to 34 weeks with a confirmed diagnosis of vulvovaginal candidiasis. The patients were divided into two equal groups: the main group included the patients who received therapy for vulvovaginal candidiasis with an antifungal drug in combination with the immunomodulatory drug Superlymph and restoration of vaginal flora with probiotics; the control group included the patients who received only antifungal therapy. Efficacy was evaluated on the basis of the analysis of clinical manifestations, microbiological and microscopic examination of vaginal discharge, pro-inflammatory cytokines.
Results: Clinical manifestations were reduced in both groups after receiving the therapy, but four patients from the control group complained of itching and discharge from the genital tract. The frequency of relapses significantly decreased and the duration of remission increased in the main group. After treatment microscopic examination showed a statistically significant decrease in the number of fungi in both groups, and the number of leukocytes and epithelial cells was decreased in the main group. Bacteriological examination revealed complete elimination of the pathogen in the main group, Candida species were isolated in 15% of patients (n=3) in the control group.
Conclusion: Complex therapy of recurrent vulvovaginal candidiasis in pregnant women with antifungal drugs in combination with the immunomodulatory drug Superlymph and probiotics normalized the vaginal microecology, reduced the number of relapses, and did not have a negative impact on maternal and perinatal outcomes.
Толық мәтін
Авторлар туралы
Victor Tyutyunnik
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Хат алмасуға жауапты Автор.
Email: tioutiounnik@mail.ru
ORCID iD: 0000-0002-5830-5099
SPIN-код: 1963-1359
Scopus Author ID: 56190621500
ResearcherId: B-2364-2015
Professor, MD, PhD, Leading Researcher of the Center for Scientific and Clinical Research
Ресей, 117997, Moscow, Ac. Oparina str., 4Natalia Kan
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: kan-med@mail.ru
ORCID iD: 0000-0001-5087-5946
SPIN-код: 5378-8437
Scopus Author ID: 57008835600
ResearcherId: B-2370-2015
Professor, MD, PhD, Deputy Director of Science
Ресей, 117997, Moscow, Ac. Oparina str., 4Yurii Tezikov
Samara State Medical University, Ministry of Health of Russia
Email: yra.75@inbox.ru
ORCID iD: 0000-0002-8946-501X
SPIN-код: 2896-6986
Scopus Author ID: 161372
ResearcherId: С-6187-2018
Professor, MD, PhD, Head of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine
Ресей, 443099, Samara, Chapaevskaya str., 89Igor Lipatov
Samara State Medical University, Ministry of Health of Russia
Email: i.lipatoff2012@yandex.ru
ORCID iD: 0000-0001-7277-7431
SPIN-код: 9625-2947
Scopus Author ID: 6603787595
ResearcherId: С-5060-2018
Professor, MD, PhD, Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine
Ресей, 443099, Samara, Chapaevskaya str., 89Olga Mikhailova
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: omikhaylova@gmail.com
ORCID iD: 0000-0001-7569-8704
PhD, Researcher of the 2nd Obstetric Physiological Department
Ресей, 117997, Moscow, Ac. Oparina str., 4Dzhamilia Mirzabekova
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: Jamilya1705@yandex.ru
ORCID iD: 0000-0002-2391-3334
graduate student
Ресей, 117997, Moscow, Ac. Oparina str., 4Әдебиет тізімі
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