Complex therapy of recurrent vulvovaginal candidiasis in pregnancy
- Authors: Tyutyunnik V.L.1, Kan N.E.1, Tezikov Y.V.2, Lipatov I.S.2, Mikhailova O.I.1, Mirzabekova D.D.1
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Affiliations:
- Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
- Samara State Medical University, Ministry of Health of Russia
- Issue: No 11 (2023)
- Pages: 150-156
- Section: Exchange of Experience
- URL: https://journals.eco-vector.com/0300-9092/article/view/626136
- DOI: https://doi.org/10.18565/aig.2023.259
- ID: 626136
Cite item
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Abstract
Objective: To analyze the clinical efficacy of combined therapy of vulvovaginal candidiasis in pregnancy.
Materials and methods: The study included 40 women who were pregnant from 13 to 34 weeks with a confirmed diagnosis of vulvovaginal candidiasis. The patients were divided into two equal groups: the main group included the patients who received therapy for vulvovaginal candidiasis with an antifungal drug in combination with the immunomodulatory drug Superlymph and restoration of vaginal flora with probiotics; the control group included the patients who received only antifungal therapy. Efficacy was evaluated on the basis of the analysis of clinical manifestations, microbiological and microscopic examination of vaginal discharge, pro-inflammatory cytokines.
Results: Clinical manifestations were reduced in both groups after receiving the therapy, but four patients from the control group complained of itching and discharge from the genital tract. The frequency of relapses significantly decreased and the duration of remission increased in the main group. After treatment microscopic examination showed a statistically significant decrease in the number of fungi in both groups, and the number of leukocytes and epithelial cells was decreased in the main group. Bacteriological examination revealed complete elimination of the pathogen in the main group, Candida species were isolated in 15% of patients (n=3) in the control group.
Conclusion: Complex therapy of recurrent vulvovaginal candidiasis in pregnant women with antifungal drugs in combination with the immunomodulatory drug Superlymph and probiotics normalized the vaginal microecology, reduced the number of relapses, and did not have a negative impact on maternal and perinatal outcomes.
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About the authors
Victor L. Tyutyunnik
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Author for correspondence.
Email: tioutiounnik@mail.ru
ORCID iD: 0000-0002-5830-5099
SPIN-code: 1963-1359
Scopus Author ID: 56190621500
ResearcherId: B-2364-2015
Professor, MD, PhD, Leading Researcher of the Center for Scientific and Clinical Research
Russian Federation, 117997, Moscow, Ac. Oparina str., 4Natalia E. Kan
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: kan-med@mail.ru
ORCID iD: 0000-0001-5087-5946
SPIN-code: 5378-8437
Scopus Author ID: 57008835600
ResearcherId: B-2370-2015
Professor, MD, PhD, Deputy Director of Science
Russian Federation, 117997, Moscow, Ac. Oparina str., 4Yurii V. Tezikov
Samara State Medical University, Ministry of Health of Russia
Email: yra.75@inbox.ru
ORCID iD: 0000-0002-8946-501X
SPIN-code: 2896-6986
Scopus Author ID: 161372
ResearcherId: С-6187-2018
Professor, MD, PhD, Head of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine
Russian Federation, 443099, Samara, Chapaevskaya str., 89Igor S. Lipatov
Samara State Medical University, Ministry of Health of Russia
Email: i.lipatoff2012@yandex.ru
ORCID iD: 0000-0001-7277-7431
SPIN-code: 9625-2947
Scopus Author ID: 6603787595
ResearcherId: С-5060-2018
Professor, MD, PhD, Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine
Russian Federation, 443099, Samara, Chapaevskaya str., 89Olga I. Mikhailova
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: omikhaylova@gmail.com
ORCID iD: 0000-0001-7569-8704
PhD, Researcher of the 2nd Obstetric Physiological Department
Russian Federation, 117997, Moscow, Ac. Oparina str., 4Dzhamilia D. Mirzabekova
Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia
Email: Jamilya1705@yandex.ru
ORCID iD: 0000-0002-2391-3334
graduate student
Russian Federation, 117997, Moscow, Ac. Oparina str., 4References
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