Complex therapy of recurrent vulvovaginal candidiasis in pregnancy

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Objective: To analyze the clinical efficacy of combined therapy of vulvovaginal candidiasis in pregnancy.

Materials and methods: The study included 40 women who were pregnant from 13 to 34 weeks with a confirmed diagnosis of vulvovaginal candidiasis. The patients were divided into two equal groups: the main group included the patients who received therapy for vulvovaginal candidiasis with an antifungal drug in combination with the immunomodulatory drug Superlymph and restoration of vaginal flora with probiotics; the control group included the patients who received only antifungal therapy. Efficacy was evaluated on the basis of the analysis of clinical manifestations, microbiological and microscopic examination of vaginal discharge, pro-inflammatory cytokines.

Results: Clinical manifestations were reduced in both groups after receiving the therapy, but four patients from the control group complained of itching and discharge from the genital tract. The frequency of relapses significantly decreased and the duration of remission increased in the main group. After treatment microscopic examination showed a statistically significant decrease in the number of fungi in both groups, and the number of leukocytes and epithelial cells was decreased in the main group. Bacteriological examination revealed complete elimination of the pathogen in the main group, Candida species were isolated in 15% of patients (n=3) in the control group.

Conclusion: Complex therapy of recurrent vulvovaginal candidiasis in pregnant women with antifungal drugs in combination with the immunomodulatory drug Superlymph and probiotics normalized the vaginal microecology, reduced the number of relapses, and did not have a negative impact on maternal and perinatal outcomes.

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作者简介

Victor Tyutyunnik

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

编辑信件的主要联系方式.
Email: tioutiounnik@mail.ru
ORCID iD: 0000-0002-5830-5099
SPIN 代码: 1963-1359
Scopus 作者 ID: 56190621500
Researcher ID: B-2364-2015

Professor, MD, PhD, Leading Researcher of the Center for Scientific and Clinical Research

俄罗斯联邦, 117997, Moscow, Ac. Oparina str., 4

Natalia Kan

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: kan-med@mail.ru
ORCID iD: 0000-0001-5087-5946
SPIN 代码: 5378-8437
Scopus 作者 ID: 57008835600
Researcher ID: B-2370-2015

Professor, MD, PhD, Deputy Director of Science

俄罗斯联邦, 117997, Moscow, Ac. Oparina str., 4

Yurii Tezikov

Samara State Medical University, Ministry of Health of Russia

Email: yra.75@inbox.ru
ORCID iD: 0000-0002-8946-501X
SPIN 代码: 2896-6986
Scopus 作者 ID: 161372
Researcher ID: С-6187-2018

Professor, MD, PhD, Head of the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine

俄罗斯联邦, 443099, Samara, Chapaevskaya str., 89

Igor Lipatov

Samara State Medical University, Ministry of Health of Russia

Email: i.lipatoff2012@yandex.ru
ORCID iD: 0000-0001-7277-7431
SPIN 代码: 9625-2947
Scopus 作者 ID: 6603787595
Researcher ID: С-5060-2018

Professor, MD, PhD, Professor at the Department of Obstetrics and Gynecology of the Institute of Clinical Medicine

俄罗斯联邦, 443099, Samara, Chapaevskaya str., 89

Olga Mikhailova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: omikhaylova@gmail.com
ORCID iD: 0000-0001-7569-8704

PhD, Researcher of the 2nd Obstetric Physiological Department

俄罗斯联邦, 117997, Moscow, Ac. Oparina str., 4

Dzhamilia Mirzabekova

Academician V.I. Kulakov National Medical Research Centre for Obstetrics, Gynecology and Perinatology, Ministry of Health of Russia

Email: Jamilya1705@yandex.ru
ORCID iD: 0000-0002-2391-3334

graduate student

俄罗斯联邦, 117997, Moscow, Ac. Oparina str., 4

参考

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