The results of prenatal screening for chromosomal pathology in Moscow


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The paper gives the data from a prenatal screening of chromosomal pathology in Moscow in 2006-2008. The detection rate for Down's syndrome was 79.1% with 6.8% false-positive results. The maximum detection rate (93.1%) for fetal chromosomal diseases can be achieved by screening methods, by simultaneously taking into account the age of a pregnant woman, biochemical markers, and fetal nuchal thickness in the first trimester of pregnancy.

Sobre autores

Mark Kurtser

Email: cfp@list.ru

V Gnetetskaya

V Mit'kin

I Kalinovskaya

Yu Kutakova

M Kurtser

Center of Family Planning and Reproduction

Center of Family Planning and Reproduction

V Gnetestskaya

Center of Family Planning and Reproduction

Center of Family Planning and Reproduction

V Mitkin

Laboratory of Neonatal Screening, Children's Mental Hospital Six

Laboratory of Neonatal Screening, Children's Mental Hospital Six

I Kalinovskaya

Moscow Department of Health Care

Moscow Department of Health Care

Yu Kutakova

Moscow Department of Health Care

Moscow Department of Health Care

Bibliografia

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  2. Bindra R., Heath V., Liao A. et al. One-stop clinic for assessment of risk for trisomy 21 at 11-14 weeks // Ultrasound Obstetr. Gynaecol. - 2002. - Vol. 20. - P. 219-225.
  3. Cuckle H. S., Spenser K., Nicolaides K. H. Down syndrome screening marker levels in women with a previous aneuploidy pregnancy // Prenat. Diagn. - 2005. - Vol. 25. - P. 47-50.
  4. Currier R. J., Flessel M. C., Goldman S., Lorey F. W. Triple marker screening in California. A ten-year review // International Down's Syndrome Screening Group. - New York, 2006. - P. 15.
  5. Kagan K. O., Avgidou K., Molina F. S. et al. Relation between increased fetal nuchal translucency thickness and chromosomal defects // Obstetr. and Gynecol. - 2006. - Vol. 107, N 1. - P. 6-10.
  6. Spencer K., Spencer C. E., Power M. Screening for chromosomal abnormalities in first trimester using ultrasound and maternal serum biochemistry in one-stop clinic // Br. J. Obstetr. Gynaecol. - 2003. - Vol. 110, N 3. - P. 281-286.

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