PREVALENCE OF ANOGENITAL HPV TYPES IN PATIENTS WITH HPV-ASSOCIATED DISEASES OF THE CERVIX UTERI
- Autores: Nazarova N.M.1, Bourmenskaya O.V.1, Sulamanidze L.A.1, Prilepskaya V.N.1, Pavlovich S.V.1, Trofimov D.Y.1
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Afiliações:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
- Edição: Nº 12 (2015)
- Páginas: 89-96
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/247569
- ID: 247569
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Resumo
Objective. To study the prevalence of different anogenital HPV types in patients with varying severity of HPV-associated cervical intraepithelial neoplasia. Subject and methods. Clinical studies, extended colposcopy; high-resolution anoscopy; cytological examination; target biopsy of the cervix uteri; histological examination of biopsy specimens; HPV typing and qualitative assessment. Results. A total of 159 women (mean age 30±12 years) were examined. Five groups were formed according to the examination results: 1) 38 (23.9%) patients with CIN I-III at that moment; 2) 41 (25.8%) with a history of CIN I-III; 3) 35 (22. 0%) with anogenital condylomas; 4) 29 (18.2%) with HPV carriage; 5) 16 (10.1%) healthy women. Cervical and anal HPV was detected in 79 (49.7%) and 65 (40.9%) patients. HPV group A9 was significantly more common in the cervical canal (OR = 2.8 (1.3-5.9), p = 0.005) whereas HPV group 10 was in the anus (OR = 2.5 (1.1-5.6), p = 0.025). The most common HPV types were 16 (41.7%), 31 (15.1%), 44, 33 (12.6%), and 52, 68 (11.3%) in the cervix and 16 (29.2%), 53 (21.5%), 66 and 44 (16.9%), 31 (13.8%), 56 and 39(12.3%), and 6(10.7%) in the anal canal. In Groups 1, 2, 3, and 4, the cervix was detected to have HPV 16 in 52.6, 4.9, 8.6, and 27.6% of cases; HPV 33 in 7.9, 2.4, 0, and 20.7%; the anal canal more frequently contained HPV 16 in 23.7, 4.8, 8.6, and 17.2%; HPV 31 in 5.3, 0, 5.7, and 17.2% of cases; HPV 66 in 2.6, 4.8, 11.4, and 13.8%; HPV 56 in 15.8, 0, 2.9, and 3.4%; HPV 53 in 13.2, 7.3, 5.7, and 13.8%. Conclusion. In the patients with HPV-associated anogenital diseases, HPV types were ascertained to be different in the cervical canal and anal area. HPV group A9 was significantly more often encountered in the epithelium of the cervical canal than in the anus of patients with CIN, which allows consideration of the presence of CIN as a risk factor for the anal area to be infected with these types of the virus.
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Sobre autores
Niso Nazarova
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: grab2@yandex.ru
MD, PhD, Senior Researcher Moscow 117997, Ac. Oparina str. 4, Russia
Olga Bourmenskaya
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: o_bourmenskaya@oparina4.ru
MD, Researcher of Molecular-genetic Laboratory Moscow 117997, Ac. Oparina str. 4, Russia
Lika Sulamanidze
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: lika.sulamanidze@gmail.com
PhD student Moscow 117997, Ac. Oparina str. 4, Russia
Vera Prilepskaya
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: VPrilepskaya@mail.ru
MD, PhD, Professor, Deputy Director for Science Moscow 117997, Ac. Oparina str. 4, Russia
Stanislav Pavlovich
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: s_pavlovich@oparina4.ru
PhD, Assistant Professor, Scientific Secretary Moscow 117997, Ac. Oparina str. 4, Russia
Dmitriy Trofimov
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of Russia
Email: d.trofimov@dna-tech.ru
MD, PhD, Molecular-genetic Laboratory Chief Moscow 117997, Ac. Oparina str. 4, Russia
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