ROLE OF CELL-FREE FETAL DNA IN THE EARLY DIAGNOSIS OF PREGNANCY COMPLICATIONS
- Autores: Gracheva M.I.1, Kan N.E.1, Krasniy A.M.1
-
Afiliações:
- Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
- Edição: Nº 10 (2016)
- Páginas: 5-11
- Seção: Articles
- URL: https://journals.eco-vector.com/0300-9092/article/view/329687
- DOI: https://doi.org/10.18565/aig.2016.10.5-10
- ID: 329687
Citar
Texto integral
![Acesso aberto](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_open.png)
![Acesso é fechado](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_unlock.png)
![Acesso é fechado](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
Resumo
Texto integral
![Acesso é fechado](https://journals.eco-vector.com/lib/pkp/templates/images/icons/text_lock.png)
Sobre autores
Maria Gracheva
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: dr.gracheva@rambler.ru
gynecologist, doctor of obstetric observation department Moscow 117997, Ac. Oparina str. 4, Russia
Nataliya Kan
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: kan-med@mail.ru
MD, head of the obstetric observation department Moscow 117997, Ac. Oparina str. 4, Russia
Alexey Krasniy
Research Center of Obstetrics, Gynecology, and Perinatology, Ministry of Health of the Russian Federation
Email: a_krasnyi@oparina4.ru
candidate of biological Sciences, head of the obstetric observation department Moscow 117997, Ac. Oparina str. 4, Russia
Bibliografia
- Lo Y.M., Corbetta N., Chamberlain P.F., Rai V., Sargent I.L., Redman C.W., Wainscoat J.S. Presence of fetal DNA in maternal plasma and serum. Lancet. 1997; 350(9076): 485-7.
- Lo Y.M. Fetal DNA in maternal plasma: biology and diagnostic applications. Clin. Chem. 2000; 46(12): 1903-6.
- Hahn S., Huppertz B., Holzgreve W. Fetal cells and cell free fetal nucleic acids in maternal blood: new tools to study abnormal placentation? Placenta. 2005; 26(7): 515-26.
- Sifakis S., Koukou Z., Spandidos D. A. Cell-free fetal DNA and pregnancy-related complications (Review). Mol. Med. Rep. 2015; 11(4): 2367-72.
- Курцер М.А., Гнетецкая В.А. Диагностика хромосомных анеуплодий с помощью неинвазивного пренатального теста. Акушерство и гинекология. 2015; 8: 65-9.
- Пантюх К.С., Шубина Е.С. Неинвазивная пренатальная диагностика анеуплоидий плода, основанная на секвенировании внеклеточной ДНК крови беременной женщины. Акушерство и гинекология. 2015; 8: 5-11
- Сухих Г.Т., Каретникова Н.А., Баранова Е.Е., Шубина Е.С., Коростин Д.О., Екимов А.Н., Парсаданян Н.Г., Гус А.И., Бахарев В.А., Трофимов Д.Ю., Воеводин С.М., Тетруашвили Н.К. Неинвазивная пренатальная диагностика анеуплоидий методом высокопроизводительного секвенирования (NGS) в группе женщин высокого риска. Акушерство и гинекология. 2015; 4: 5-10
- Lo Y.M., Leung T.N., Tein M.S., Sargent I.L., Zhang J., Lau T.K. et al. HQuantitative abnormalities of fetal DNA in maternal serum in preeclampsia. Clin. Chem. 1999; 45(2): 184-8.
- Leung T.N., Zhang J., Lau T.K., Chan L.Y., Lo Y.M. Increased maternal plasma fetal DNA concentrations in women who eventually develop preeclampsia. Clin. Chem. 2001; 47(1): 137-9.
- Zhong X.Y., Holzgreve W., Hahn S. The levels of circulatory cell free fetal DNA in maternal plasma are elevated prior to the onset of preeclampsia. Hypertens. Pregnancy. 2002; 21(1): 77-83.
- Levine R.J., Qian C., Leshane E.S., Yu K.F., England L.J., Schisterman E.F. et al. Two-stage elevation of cell-free fetal DNA in maternal sera before onset of preeclampsia. Am. J. Obstet. Gynecol. 2004; 190(3): 707-13.
- Zimmermann B., El-Sheikhah A., Nicolaides K., Holzgreve W., Hahn S. Optimized real-time quantitative PCR measurement of male fetal DNA in maternal plasma. Clin. Chem. 2005; 51(9): 1598-604.
- Crowley A., Martin C., Fitzpatrick P., Sheils O., O’ Herlihy C., O’ Leary J.J., Byrne B.M. Free fetal DNA is not increased before 20 weeks in intrauterine growth restriction or pre-eclampsia. Prenat. Diagn. 2007; 27(2): 174-9.
- Poon L.C., Musci T., Song K., Syngelaki A., Nicolaides K.H. Maternal plasma cell-free fetal and maternal DNA at 11-13 weeks’ gestation: relation to fetal and maternal characteristics and pregnancy outcomes. Fetal Diagn. Ther. 2013; 33(4): 215-23.
- Stein W., Müller S., Gutensohn K., Emons G., Legler T. Cell-free fetal DNA and adverse outcome in low risk pregnancies. Eur. J. Obstet. Gynecol. Reprod. Biol. 2013; 166(1): 10-3.
- Sifakis S., Zaravinos A., Maiz N., Spandidos D.A., Nicolaides K.H. First-trimester maternal plasma cell-free fetal DNA and preeclampsia. Am. J. Obstet. Gynecol. 2009; 201(5): 472. e1-7.
- Scharfe-Nugent A., Corr S.C., Carpenter S.B., Keogh L., Doyle B., Martin C. et al. TLR9 provokes inflammation in response to fetal DNA: mechanism for fetal loss in preterm birth and preeclampsia. J. Immunol. 2012; 188(11): 5706-12.
- Gourvas V., Dalpa E., Konstantinidou A., Vrachnis N., Spandidos D.A., Sifakis S. Angiogenic factors in placentas from pregnancies complicated by fetal growth restriction (Review). Mol. Med. Rep. 2012; 6(1): 23-7.
- Sekizawa A., Jimbo M., Saito H., Iwasaki M., Matsuoka R., Okai T., Farina A. Cell-free fetal DNA in the plasma of pregnant women with severe fetal growth restriction. Am. J. Obstet. Gynecol. 2003; 188(2): 480-4.
- Smid M., Galbiati S., Lojacono A., Valsecchi L., Platto C., Cavoretto P. et al. Correlation of fetal DNA levels in maternal plasma with Doppler status in pathological pregnancies. Prenat. Diagn. 2006; 26(9): 785-90.
- Alberry M.S., Maddocks D.G., Hadi M.A., Metawi H., Hunt L.P., Abdel-Fattah S.A. et al. Quantification of cell free fetal DNA in maternal plasma in normal pregnancies and in pregnancies with placental dysfunction. Am. J. Obstet. Gynecol. 2009; 200(1): 98. e1-6.
- Al Nakib M., Desbriere R., Bonello N., Bretelle F., Boubli L., Gabert J., Levi-Mozziconacci A. Total and fetal cell-free DNA analysis in maternal blood as markers of placental insufficiency in intrauterine growth restriction. Fetal Diagn. Ther. 2009; 26(1): 24-8.
- Парсаданян Н.Г., Шубина Е.С., Тетруашвили Н.К., Трофимов Д.Ю., Сухих Г.Т. Уровень свободной эмбриональной ДНК при угрожающем, привычном выкидыше и неосложненном течении беременности в сроках до 22 недель. Акушерство и гинекология 2015; 2: 33-8.
- Hoesli I., Danek M., Lin D., Li Y., Hahn S., Holzgreve W. Circulating erythroblasts in maternal blood are not elevated before onset of preterm labor. Obstet. Gynecol. 2002; 100(5, Pt1): 992-6
- Farina A., LeShane E.S., Romero R., Gomez R., Chaiworapongsa T., Rizzo N., Bianchi D.W. High levels of fetal cell-free DNA in maternal serum: a risk factor for spontaneous preterm delivery. Am. J. Obstet. Gynecol. 2005; 193(2): 421-5.
- Iiianes S., Gomez R., Fornes R., Figueroa-Diesel H., Schepeier M., Searovic P. et al. Free fetal DNA levels in patients at risk of preterm labour. Prenat. Diagn. 2011; 31(11): 1082-5.
- Jakobsen T.R., Clausen F.B., Rode L., Dziegiei M.H., Tabor A. High levels of fetal DNA are associated with increased risk of spontaneous preterm delivery. Prenat. Diagn. 2012; 32(9): 840-5.
- Ei-Garf W., Sheba M., Saiama S., Fouad R., Ei-Shenawy M., Bibers M., Azmy O. Assesment of plasma cell-free fetal DNA using hypermethylated RASSF1A in maternal plasma in cases of spontaneous preterm labor. Med. Res. J. 2013; 12(2): 49-52.
- Quezada M.S., Francisco C., Dumitrascu-Biris K., Nicoiaides K.H., Poon L.C. Fetal fraction of cell-free DNA in maternal plasma in the prediction of spontaneous preterm delivery. Ultrasound Obstet. Gynecol. 2015; 45(1): 101-5.
- Парсаданян Н.Г., Шубина Е.С., Тетруашвили Н.К., Агаджанова А.А., Трофимов Д.Ю. Уровень свободной эмбриональной ДНК у пациентки с привычным выкидышем и тяжелой плацентарной недостаточностью. Акушерство и гинекология. 2015; 4: 90-4. [Parsadanyan N.G., Shubina E.S., Tetruashvili N.K., Agadzhanova A.A., Trofimov D.Yu. Free embryonic DNA levels in a patient with recurrent miscarriage and severe placental insufficiency. Akusherstvo i ginekologiya/Obstetrics and Gynecology. 2015; (4): 90-4. (in Russian)]
- Vora N.L., Johnson K.L., Basu S., Catalano P.M., Hauguei-De Mouzon S., Bianchi ID.W. A multifactorial relationship exists between total circulating cell-free DNA levels and maternal BMI. Prenat. Diagn. 2012; 32(9): 912-4.
- Haghiac M., Vora N.L., Basu S., Johnson K.L., Presiey L., Bianchi D.W., Hauguei-De Mouzon S. Increased death of adipose cells, a path to release cell free DNA into systemic circulation of obese women. Obesity (Silver Spring). 2012; 20(11): 2213-9.
- Kim M.J., Kim S.Y., Park S.Y., Ahn H.K., Chung J.H., Ryu H.M. Association of fetal derived hypermethylated RASSF1A concentration in placenta-mediated pregnancy complications. Placenta. 2013; 34(1): 57-61.
- Sekizawa A., Sugito Y., Iwasaki M., Watanabe A., Jimbo M., Hoshi S. et al. Cell-free fetal DNA is increased in plasma of women with hyperemesis gravidarum. Clin. Chem. 2001; 47(12): 2164-5.
- Sugito Y., Sekizawa A., Farina A., Yukimoto Y., Saito H., Iwasaki M. et al. Relationship between severity of hyperemesis gravidarum and fetal DNA concentration in maternal plasma. Clin. Chem. 2003; 49(10): 1667-9.
Arquivos suplementares
![](/img/style/loading.gif)