Comparative analysis of pharmaceutical markets for liver disease drugs in the Republic of Algeria and the Russian Federation

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Abstract

Introduction. Aging population, increasing prevalence of liver diseases, government initiatives to provide vaccines and growing awareness, lifestyle changes that lead to increase in diseases associated with this lifestyle, increased alcohol consumption and improper dietary habits are expected to drive the growth of the liver disease therapeutics market. In the Republic of Algeria, the majority of drugs in the pharmaceutical market are generics or imported drugs, including in hepatology.

The aim of the study is to determine the needs of the pharmaceutical market in the Republic of Algeria for the prevention and treatment of liver diseases in order to create a domestic drug.

Material and methods. The study was conducted by analyzing the assortment of drugs for the prevention and treatment of liver diseases in the pharmaceutical markets of the Republic of Algeria and the Russian Federation based on the data of national lists and registers of drugs. The selection of promising plant candidates was based on the analysis of scientific literature on the species used in Russian drugs, taking into account the biodiversity of the Mediterranean flora.

Results. Comparative analysis revealed significant differences. The market of the Republic of Algeria is dominated by imported antispasmodics (57%), which are the only herbal preparations, whereas the Russian market demonstrates a wide range of phytotherapeutic agents (21.2%).

Conclusion. The scarcity of herbal preparations for the treatment of liver diseases in the Republic of Algeria requires the development of new drugs. Three species of local plants – milk thistle, artichoke and rosemary – which have liver-protective properties, were selected as promising candidates.

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About the authors

Sofia Sahraoui

Belgorod State National Research University

Email: sofiasahraoui95@gmail.com
ORCID iD: 0009-0003-2146-762X

2nd-Year Postgraduate Student, Scientific Specialty 3.4.1 Industrial Pharmacy and Technology of Drug Production at the Institute of Pharmacy, Chemistry and Biology

Russian Federation, Belgorod

Elena Theodorovna Zhilyakova

Belgorod State National Research University

Author for correspondence.
Email: EZhilyakova@bsu.edu.ru
ORCID iD: 0000-0002-8685-1601

Doctor of Pharmaceutical Sciences, Professor, Head of the Department of Pharmaceutical Technology of the Institute of Pharmacy, Chemistry and Biology

Russian Federation, Belgorod

References

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Supplementary files

Supplementary Files
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2. Fig. 1. Structure of drugs for the treatment of liver diseases on the Russian market in relation to the number of drugs and biologically active food supplements

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3. Fig. 2. The range of medicines used for liver diseases included in the nomenclature of the Ministry of Pharmaceutical Industry of the Republic of Algeria

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4. Fig. 3. Classification of drugs used for the treatment of liver diseases by active ingredients approved by the Algerian Ministry of Pharmaceutical Industry

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5. Fig. 4. Spectrum of medicinal products for the treatment of liver diseases included in the register of medicinal products of the Russian Federation by categories of active ingredients

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6. Fig. 5. Assortment of domestic and foreign medicines intended for therapy of liver diseases included in the list approved by the Ministry of Pharmaceutical Industry of the Republic of Algeria

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