Pectoral species No. 4: molybdenum, tungsten, lithium, vanadium, titanium and zirconium content

Cover Page

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Introduction. In medicinal plants, elements are contained in available biogenic complexes. Ultramicroelements (selenium, cobalt, chromium, molybdenum, lithium and others) enter the human body with water, food, medicinal preparations and participate in various biochemical processes. Unlike macro- and micronutrients, information on the content of ultramicroelements in the complex plant preparations is practically absent.

Purpose of the study. Study of pectoral species No.4 and medicinal forms on its basis as a potential source of ultramicroelements in the human body.

Material and methods. Objects – pectoral species No.4, its components, dry extract and infusions from them. Elemental analysis was carried out by inductively coupled plasma atomic emission spectrometry on an ICP-AES 720-ES device (Agilent Technologies) with preliminary acid mineralisation.

Results. The concentration of ultramicroelements (Mo, W, Li, V, Ti, Zr) in various components and in pectoral species No. 4 varied in the range of 0.48–101.02 mg/kg, the transition of these elements in infusions was 0.39–28.06% of the initial content in raw materials. It was found that the daily intake of molybdenum and vanadium with infusion from the pectoral species can reach respectively 42 and 100% of the daily physiological requirement. Breast collection №4 can be considered as an additional source of ultramicroelements in the human body.

Full Text

Restricted Access

About the authors

Irina V. Gravel

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Author for correspondence.
Email: gravel_i_v@staff.sechenov.ru
ORCID iD: 0000-0002-3735-2291
SPIN-code: 2844-7091

Doctor of Pharmaceutical Sciences, Professor, Professor of the Pharmaceutical Natural Sciences Department

Russian Federation, Trubetskaya St., 8, bld. 2, Moscow, 119991

Dmitry V. Levushkin

I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: istomam@gmail.com
ORCID iD: 0000-0002-7782-1574
SPIN-code: 7834-0525

PhD student in pharmaceutical sciences of the Pharmaceutical Natural Sciences Department

Russian Federation, Trubetskaya St., 8, bld. 2, Moscow, 119991

References

  1. Гальченко А.В., Назарова А.М. Эссенциальные микро- и ультрамикроэлементы в питании вегетарианцев и веганов. Ч. 1. Железо, цинк, медь, марганец. Микроэлементы в медицине. 2019; 20 (4): 14–23. [Galchenko A.V., Nazarova A.M. Essential micro- and ultramicroelements in the nutrition of vegetarians and vegans. Part 1. Iron, zinc, copper, manganese. Mikroelementy v medicine. 2019; 20 (4): 14–23. doi: 10.19112/2413-6174-2019-20-4-14-23 (In Russian)].
  2. Авцын А.П. и др. Микроэлементозы человека. М.: Медицина, 1991; 496. [Avtsyn A.P. et al. Human microelementosis. Moscow: Medicine, 1991; 496 (In Russian)].
  3. Дыгова М.Р., Кубалова Л.М. Биологическая роль молибдена. Международный студенческий научный вестник. 2015; 3–4: 550–1. [Dygova M.R., Kubalova L.M. Biological role of molybdenum. Mezhdunarodnyj studencheskij nauchnyj vestnik. 2015; 3–4: 550–1 (In Russian)].
  4. Радыш И.В., Скальный А.В., Нотова С.В. Введение в элементологию: учебное пособие. Оренбургский государственный университет. 2017; 184. [Radysh I.V., Skalny A.V., Notova S.В. Introduction to elementology: textbook. Orenburgskij gosudarstvennyj universitet. 2017; 184 (In Russian)].
  5. Hille R., Schulzke C., Kirk M. L. Molybdenum and tungsten enzymes: Biochemistry. Royal Society of Chemistry. 2016; 343.
  6. Hadrup N., Sørli J.B., Sharma A.K. Pulmonary toxicity, genotoxicity, and carcinogenicity evaluation of molybdenum, lithium, and tungsten: A review. Toxicology. 2022; 467: 153098. doi: 10.1016/j.tox.2022.153098.
  7. Bolt A.M. Tungsten toxicity and carcinogenesis. Adv Pharmacol. 2023; 96: 119–50. doi: 10.1016/bs.apha.2022.10.004.
  8. Airainer M., Seifert R. Lithium, the gold standard drug for bipolar disorder: analysis of current clinical studies. Naunyn-Schmiedeberg's Archives of Pharmacology. 2024; 397 (12): 9723–43. doi: 10.1007/s00210-024-03210-8.
  9. Rehder D. The role of vanadium in biology. Metallomics. 2015; 7 (5): 730–42. doi: 10.1039/c4mt00304g.
  10. Rehder D. Vanadium. Its role for humans. Met Ions Life Sci. 2013; 13: 139–69. doi: 10.1007/978-94-007-7500-8_5.
  11. Тарантин А.В., Землянова М.А. Эссенциальная роль и токсические эффекты ванадия. Экология человека. 2015; 12: 59–64. [Tarantin A.V., Zemlyanova M.A. Essential role and toxic effects of vanadium. Ekologiya cheloveka. 2015; 12: 59–64. doi: 10.17816/humeco16967 (In Russian)].
  12. Скальный А.В. и др. Биоэлементология: основные понятия и термин. Оренбург: ГОУ ОГУ. 2005; 353. [Skalny A.V. et al. Bioelementology: basic concepts and term. Orenburg: GOU OGU. 2005; 353 (In Russian)].
  13. Аляхнович Н.С., Новиков Д.К. Взаимодействие диоксида титана с биологическими средами организма. Иммунопатология, аллергология, инфектология. 2016; 1: 37–42. [Alyakhnovich N.S., Novikov D.K. Interaction of titanium dioxide with biological media of the organism. Immunopatologiya, allergologiya, infektologiya. 2016; 1: 37–42. doi: 10.14427/jipai.2016.1.37 (In Russian)].
  14. Wang J. et al. Acute toxicity and biodistribution of different sized titanium dioxide articles in mice after oral administration. Toxicology letters. 2007;168 (2): 176–85. doi: 10.1016/j.toxlet.2006.12.001.
  15. Готь С.Р. Использование оксида циркония и титана в дентальной имплантологии на современном этапе. Вестник стоматологии. 2017; 2 (99): 65–71. [Goth S.R. Use of zirconium oxide and titanium in dental implantology at the present stage. Vestnik stomatologii. 2017; 2 (99): 65–71 (In Russian)].
  16. Лысиков Ю.А. Роль и физиологические основы обмена макро-и микроэлементов в питании человека. Экспериментальная и клиническая гастроэнтерология. 2009; 2: 120–31. [Lysikov Y.A. Role and physiological basis of macro- and microelements metabolism in human nutrition. Eksperimentalnaya i klinicheskaya gastroenterologiya. 2009; 2: 120–31 (In Russian)].
  17. Shirani M. et al. A review of Toxicity studies of Zirconium and its derivatives. Jundishapur J. of Natural Pharmaceutical Products. 2023; 8 (4): 137464. doi: 10.5812/jjnpp-137464.
  18. Raufov A.A., Naimova S.A. The influence of deficiency of microelements in children with bronchial hyperreactivity. Vestnik nauki i obrazovaniya. 2020; 24–2 (102): 63–9.
  19. Отмахов В. и др. Исследование элементного состава растений флоры Сибири (Alfredia cernua и Filipendula ulmaria), экстрактов и фракций для создания лекарственных препаратов на их основе. Химия растительного сырья. 2019; 3: 205–16. [Otmakhov V. et al. Investigation of elemental composition of plants of Siberian flora (Alfredia cernua and Filipendula ulmaria), extracts and fractions for creation of medicinal preparations on their basis. Himiya rastitelnogo syrya. 2019; 3: 205–16 doi: 10.14258/jcprm.2019035355 (In Russian)].
  20. Pohl P. et al. The determination of elements in herbal teas and medicinal plant formulations and their tisanes. Journal of Pharmaceutical and Biomedical Analysis. 2016; 130: 326–35. doi: 10.1016/j.jpba.2016.01.042.
  21. Кабата-Пендиас А., Пендиас X. Микроэлементы в почвах и растениях. М: Издательство “Мир”, 1989; 439. [Cabata-Pendias A., Pendias X. Micronutrients in soils and plants. M: Mir, 1989; 439 (In Russian)].
  22. Shakolnik M.Y. Trace elements in plants. New York: Elsevier, 1984; 21–38.
  23. Гравель И.В. и др. Содержание макроэлементов в грудном сборе №4. Традиционная медицина. 2021; 3: 19–26. [Gravel I.V. et al. Macronutrient content of macronutrients in breast collection No. 4. Tradicionnaya medicina. 2021; 3: 19–26. doi: 10.54296/18186173_2021_3_19 (In Russian)].
  24. Гравель И.В., Лёвушкин Д.В. Содержание минорных элементов в грудном сборе №4. Разработка и регистрация лекарственных средств. 2023; 12 (2): 113–23. [Gravel I.V., Levushkin D.V. Content of minor elements in breast collection No. 4. Razrabotka i registraciya lekarstvennyh sredstv. 2023; 12 (2): 113–23. DOI: 0.33380/2305-2066-2023-12-2-113-123 (In Russian)].
  25. ОФС.1.5.3.0009.15 «Определение содержания тяжелых металлов и мышьяка в лекарственном растительном сырье и лекарственных растительных препаратах». Государственная фармакопея Российской Федерации. XIV изд. Т. II. М.; 2018. [OFS.1.5.3.0009.15. Determination of heavy metals and arsenic content in medicinal plant raw materials and medicinal plant preparations. State Pharmacopoeia of the Russian Federation. XIV ed. Vol. II. M.; 2018. (In Russian)].
  26. Методические рекомендации «Рациональное питание. Рекомендуемые уровни потребления пищевых и биологически активных веществ». 2004. [Methodological recommendations ‘Rational nutrition. Recommended levels of consumption of food and biologically active substances’. 2004 (In Russian)].

Supplementary files

Supplementary Files
Action
1. JATS XML
2. Fig. 1. Lithium content in species pectoralis No. 4 and its components, mg/kg

Download (76KB)
3. Fig. 2. Lithium content in water infusions of species pectoralis No. 4 and its components, mg/kg

Download (79KB)

Copyright (c) 2025 Russkiy Vrach Publishing House