Study of flavonoids profile of linden flowers
- 作者: Rodin M.N.1, Bokov D.O.1,2, Lazareva N.B.1
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隶属关系:
- Sechenov First Moscow State Medical University (Sechenov University)
- Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
- 期: 卷 73, 编号 3 (2024)
- 页面: 10-14
- 栏目: Pharmaceutical chemistry and pharmacognosy
- URL: https://journals.eco-vector.com/0367-3014/article/view/633221
- DOI: https://doi.org/10.29296/25419218-2024-03-02
- ID: 633221
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详细
Introduction. Linden flowers are pharmacopoeial medicinal plant raw materials. It is widely used in clinical practice for the treatment and prevention of respiratory diseases. Despite the high degree of scientific study of this MPRMs, the improvement of approaches to standardization remains a pressing issue.
Objective: study the composition of flavonoids of industrially produced linden flowers, presented on the Russian pharmaceutical market.
Material and methods. Ultra-high-performance liquid chromatography with photodiode array and tandem quadrupole mass-selective detection in the gradient elution mode was used to analyze flavonoids in industrial samples of linden flowers. Extraction was performed with 70% aqueous methanol in a water bath.
Results. The presence of flavonoids characteristic for linden flowers was confirmed. 13 flavonoids were identified (quercetin-3-rutinosid-7-rhamnoside, quercetin-3-glucoside-7-rhamnoside, tiliroside, rutin, quercetin-3-glucoside, kaempferitrin, kaempferol 3-rutinosid, quercetin-3-arabinoside, astragalin, quercetin 3-rhamnoside, kaempferol 7-rhamnoside, quercetin 3-glucuronide, prunetin-4'-rutinosid).
Conclusion. During the experiment, a flavonoid profile was identified and it is consistent with literature data. When standardizing linden flowers and medicinal herbal preparations based on them, it is recommended to use quercetin and kaempferol derivatives as marker compounds. These compounds are specific and the inclusion of a definition of this group of biologically active compounds in the RD to confirm authenticity seems very relevant when standardizing linden flowers.
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作者简介
Mikhail Rodin
Sechenov First Moscow State Medical University (Sechenov University)
Email: m.rodin2010@yandex.ru
ORCID iD: 0000-0001-9532-6879
PhD Student at Pharmaceutical Natural Sciences Department at Institute of Pharmacy named after A.P. Nelyubin
俄罗斯联邦, MoscowDmitry Bokov
Sechenov First Moscow State Medical University (Sechenov University); Federal State Budgetary Scientific Institution “Federal Research Center of Nutrition and Biotechnology”
Email: bokov_d_o@staff.sechenov.ru
ORCID iD: 0000-0003-2968-2466
PhD in Pharmaceutical Sciences, Associate Professor of the Pharmaceutical Natural Sciences Department at Institute of Pharmacy named after A.P. Nelyubin; Researcher of Laboratory of Chemistry of Food Products
俄罗斯联邦, Moscow; MoscowNatalya Lazareva
Sechenov First Moscow State Medical University (Sechenov University)
编辑信件的主要联系方式.
Email: lazareva_n_b@staff.sechenov.ru
Doctor of Medical Sciences, Associate Professor, Professor of the Department of Clinical Pharmacology and Internal Medicine Propaedeutics
俄罗斯联邦, Moscow参考
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