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Molecular mechanisms of control of differentiation of regulatory t-lymphocytes by exogenous melatonin
- Authors: Glebezdina N.S.1, Olina A.A.2, Nekrasova I.V.1, Kuklina E.M.1
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott
- Issue: Vol 484, No 2 (2019)
- Pages: 224-227
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/11735
- DOI: https://doi.org/10.31857/S0869-56524842224-227
- ID: 11735
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Abstract
We investigated the role of epiphyseal hormone melatonin in the differentiation of naive CD4+T cells into regulatory T cells (Treg). The hormone at physiological and pharmacological concentrations inhibited Treg differentiation, decreasing both the proportion of CD4+FOXP3+ cells in the culture and the level of TGF‑β, the key cytokine for this T cell subpopulation. The inhibitory effect of exogenous melatonin was due to its interaction with the membrane receptors MT1 and MT2. At the same time, the signals realized through RORa — the nuclear receptor for melatonin — stimulated Treg formation; however, they were considerably weaker than the signals from the membrane receptors and were overlapped by the latter. Since the Treg subpopulation plays an important role in physiological and pathological processes in the body, the revealed effects of melatonin should be taken into account in its therapeutic use.
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About the authors
N. S. Glebezdina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: glebezdina_n@mail.ru
Russian Federation, 13a, Lenina street, Perm, 614990
A. A. Olina
The Research Institute of Obstetrics, Gynecology and Reproductology named after D.O.Ott
Email: glebezdina_n@mail.ru
Russian Federation, 3, Mendeleevskaya line, Saint Petersburg, 199034
I. V. Nekrasova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
Russian Federation, 13a, Lenina street, Perm, 614990
E. M. Kuklina
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: glebezdina_n@mail.ru
Russian Federation, 13a, Lenina street, Perm, 614990
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