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Oncogene c-MYC controls the expression of PHF10 subunit of PBAF chromatin remodeling complex in SW620 cell line
- Authors: Tatarskiy E.V.1, Georgiev G.P.1, Soshnikova N.V.1
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Affiliations:
- Institute of Gene Biology of the Russian Academy of Sciences
- Issue: Vol 484, No 5 (2019)
- Pages: 633-636
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12789
- DOI: https://doi.org/10.31857/S0869-56524845633-636
- ID: 12789
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Abstract
The PBAF(SWI/SNF) multiprotein complex, which changes the chromatin structure, is widely involved in the regulation of eukaryotic gene expression. A specific component of this complex is the PHF10 protein, which is involved in recruiting this complex to chromatin. We showed that the PHF10 expression in cells of different lines is activated by the c-MYC oncogene. Since PHF10 stimulates cell proliferation, its c-MYC-dependent activation in cancer cells should lead to an increase in their proliferation rate.
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About the authors
Eu. V. Tatarskiy
Institute of Gene Biology of the Russian Academy of Sciences
Author for correspondence.
Email: so2615nat@gmail.com
Russian Federation, Moscow
G. P. Georgiev
Institute of Gene Biology of the Russian Academy of Sciences
Email: so2615nat@gmail.com
Academician of the RAS
Russian Federation, MoscowN. V. Soshnikova
Institute of Gene Biology of the Russian Academy of Sciences
Email: so2615nat@gmail.com
Russian Federation, Moscow
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