Email this article Electrospray preparation of biocompatible lactide–glycolide copolymer capsules with incorporation of interferon
- Authors: Khlusov I.A.1,2,3,4, Kibler E.V.2, Kudryavtseva V.L.2, Tverdokhlebov S.I.2, Bolbasov E.N.2, Botvin V.V.1, Latypov A.D.1, Gazatova N.D.4, Litvinova L.S.4, Buznik V.M.1, Choynzonov E.L.2,5
-
Affiliations:
- Tomsk State University
- National Research Tomsk Polytechnic University
- Siberian State Medical University
- Immanuel Kant Baltic Federal University
- Tomsk National Research Medical Center, Russian Academy of Science
- Issue: Vol 484, No 6 (2019)
- Pages: 703-708
- Section: Chemical Technology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12878
- DOI: https://doi.org/10.31857/S0869-56524846703-708
- ID: 12878
Cite item
Full Text
Abstract
The electrospray method was used for the first time to prepare polymeric capsules from bioresorbable dl-lactide and glycolide copolymer loaded with biological molecules from the cell secretome and, in particular, human interferon a-2b (IFN a-2b). The obtained nearly spherical submicron capsules were studied by scanning electron and confocal laser microscopy. The capsules retain the structural integrity and the cytotoxic activity of IFN a-2b towards tumor cells. The electrospray method is distinguished by high adaptability and environmental safety and is suitable for manufacture of a broad range of materials with different composition and morphology promising for the targeted delivery of drugs and biological molecules.
About the authors
I. A. Khlusov
Tomsk State University; National Research Tomsk Polytechnic University; Siberian State Medical University; Immanuel Kant Baltic Federal University
Author for correspondence.
Email: khlusov63@mail.ru
Russian Federation, 34a, Lenina prospect, Tomsk, 634050; 30, Lenin Avenue,Tomsk, 634034; 2, Moscowski Trakt, Tomsk, 634050; ul. Nevskogo, 14, Kaliningrad, 236041
E. V. Kibler
National Research Tomsk Polytechnic University
Email: khlusov63@mail.ru
Russian Federation, 30, Lenin Avenue,Tomsk, 634034
V. L. Kudryavtseva
National Research Tomsk Polytechnic University
Email: khlusov63@mail.ru
Russian Federation, 30, Lenin Avenue,Tomsk, 634034
S. I. Tverdokhlebov
National Research Tomsk Polytechnic University
Email: khlusov63@mail.ru
Russian Federation, 30, Lenin Avenue,Tomsk, 634034
E. N. Bolbasov
National Research Tomsk Polytechnic University
Email: khlusov63@mail.ru
Russian Federation, 30, Lenin Avenue,Tomsk, 634034
V. V. Botvin
Tomsk State University
Email: khlusov63@mail.ru
Russian Federation, 34a, Lenina prospect, Tomsk, 634050
A. D. Latypov
Tomsk State University
Email: khlusov63@mail.ru
Russian Federation, 34a, Lenina prospect, Tomsk, 634050
N. D. Gazatova
Immanuel Kant Baltic Federal University
Email: khlusov63@mail.ru
Russian Federation, ul. Nevskogo, 14, Kaliningrad, RUSSIA 236041
L. S. Litvinova
Immanuel Kant Baltic Federal University
Email: khlusov63@mail.ru
Russian Federation, ul. Nevskogo, 14, Kaliningrad, RUSSIA 236041
V. M. Buznik
Tomsk State University
Email: khlusov63@mail.ru
Academician of the RAS
Russian Federation, 34a, Lenina prospect, Tomsk, 634050E. L. Choynzonov
National Research Tomsk Polytechnic University; Tomsk National Research Medical Center, Russian Academy of Science
Email: khlusov63@mail.ru
Academician of the RAS
Russian Federation, 30, Lenin Avenue,Tomsk, 634034; 5, Kooperativny Str., Tomsk, 634009References
- Danhier F., Ansorena E., Si/va J. M., Coco R., Breton A., Preat V. // J. Control. Release. 2012. V. 161. № 2. P. 505-522.
- Freiberg S., Zhu X. X. // Intern. J. Pharmaceutics. 2004. V. 282. P. 1-18.
- Bock N., Dargavi//e T. R., Woodruff M. A. // Prog. Polym. Sci. 2012. V. 37. № 11. P. 1510-1551.
- Mir M., Ahmed N., Rehman A. U. // Colloids Surf. B. Biointerfaces. 2017. V. 159. P. 217-231.
- Биологические методы лечения онкологических заболеваний / Под ред. В.Т. ДеВита, С. Хеллмана, С.А. Розенберга. М.: Медицина, 2002. С. 362-381.
- Danks L., Takayanagi H. Immunology and Bone // J. Biochem. 2013. V. 154. P. 29-39.
- Timin A. S., Gou/d D. J., Sukhorukov G. B. // Expert Opin. Drug. Del. 2017. V. 14. № 5. P. 583-587.
- Kurzina I. A., Pukhova I. V., Botvin V. V., Fi/imoshkin A. G., Savkin K. P., Oskomov K. V., Oks E. M., Pukhova I. M. // AIP Conf. Proc. 2015. V. 1688. P. 030033-1-030033-7.
- Botvin V., Pozdniakov M., Fi/imoshkin A. // Polymer Degradation and Stability. 2017. V. 146. P. 126-131.
- Hungerford G., Benesch J., Mano J. F., Reis R. L. // Pho- tochem. Photobiol. Sci. 2007. V. 67. № 2. P. 152-158.
- Xie J., Lim L. K., Phua Y., Hua J., Wang C. H. // J. Colloid Interface Sci. 2006. V. 302. № 1. P. 103-112.
- Sanchez A., Tobio M., Gonzalez L., Fabra A., A/onso M. J. // Eur. J. Pharm. Sci. 2003. V. 18. № 3/4. P. 221-229.
- Yang F., Song F. L., Pan Y. F., Wang Z. Y., Yang Y. Q., Zhao Y. M., Liang S. Z., Zhang Y. M. // J. Microencap- sul. 2010. V. 27. № 2. P. 133-141.
- Berezovskaya I. V. // Pharmaceutical Chem. J. 2003. V. 37. № 3. P. 139-141
Supplementary files
