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Dipeptide mimetic of the bdnf loop 4 possesses analgetic activity
- Authors: Gudasheva T.A.1, Konstantinopolsky M.A.1, Tarasiuk A.V.1, Kolik L.G.1, Seredenin S.B.1
- Affiliations:
- Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
- Issue: Vol 485, No 3 (2019)
- Pages: 366-369
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12886
- DOI: https://doi.org/10.31857/S0869-56524853366-369
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Abstract
Previously, we synthesized a dimeric dipeptide mimetic of the brain-derived neurotrophic factor (BDNF) loop 4, GSB-106, which, similarly to BDNF, activated TrkB, PI3K/AKT, and MAPK/ERK. When administered systemically, it exhibited neuroprotective, antidepressant, and antidiabetic activities and stimulated neurogenesis and synaptogenesis. In this study, we established that GSB-106 also exhibits the analgesic activity, typical for BDNF, which was revealed in rats in hot plate and tail flick tests 0.5–48 h after intraperitoneal injection at doses of 0.1 and 1 mg/kg.
T. A. Gudasheva
Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Author for correspondence.
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow
corresponding member of the RAS
M. A. Konstantinopolsky
Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow
A. V. Tarasiuk
Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow
L. G. Kolik
Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow
S. B. Seredenin
Zakusov State Foundation Institute of Pharmacology of the Russian Academy of Medical Sciences
Email: tata-sosnovka@mail.ru
Russian Federation, Moscow
academician of the RAS
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