Email this article Innate immune protein Tag7 stimulates the appearance of cytotoxic NK cells after incubation with lymphocytes
- Authors: Sharapova T.N.1, Romanova E.A.1, Sashchenko L.P.1, Gnuchev N.V.1, Yashin D.V.1
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Affiliations:
- Institute of Gene Biology, Russian Academy of Sciences
- Issue: Vol 484, No 6 (2019)
- Pages: 777-780
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/12905
- DOI: https://doi.org/10.31857/S0869-56524846777-780
- ID: 12905
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Abstract
Tag7 (PGRP-S) is an innate immune protein that is involved in the antibacterial and antitumor defense and stimulates the maturation of cytotoxic lymphocyte subpopulations. It was found that the incubation of lymphocytes with Tag7 for 3 days promotes the appearance of cytotoxic NK cells that are active against a number of tumor cell lines.
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About the authors
T. N. Sharapova
Institute of Gene Biology, Russian Academy of Sciences
Author for correspondence.
Email: sharapovatat.nik@gmail.com
Russian Federation, Moscow
E. A. Romanova
Institute of Gene Biology, Russian Academy of Sciences
Email: sharapovatat.nik@gmail.com
Russian Federation, Moscow
L. P. Sashchenko
Institute of Gene Biology, Russian Academy of Sciences
Email: sharapovatat.nik@gmail.com
Russian Federation, Moscow
N. V. Gnuchev
Institute of Gene Biology, Russian Academy of Sciences
Email: sharapovatat.nik@gmail.com
Corresponding Member of the RAS
Russian Federation, MoscowD. V. Yashin
Institute of Gene Biology, Russian Academy of Sciences
Email: sharapovatat.nik@gmail.com
Russian Federation, Moscow
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