Email this article Peroxide-induced oxidative modification of hemoglobin
- Authors: Vasilyeva A.D.1, Yurina L.V.1, Bugrova A.E.1, Indeykina M.I.1,2, Azarova D.Y.1,3, Bychkova A.V.1, Akzhigitova K.I.1,4, Kononikhin A.S.1,5,2, Nikolaev E.N.1,5,6, Rosenfeld M.A.1
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Affiliations:
- Institute of Biochemical Physics of the Russian Academy of Sciences
- Moscow Institute of Physics and Technology
- Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin
- Belinsky pedagogical Institute of Penza State University
- Talrose Institute for EnergyProblems of Chemical Physics of the Russian Academy of Sciences
- Skolkovo Institute of Science and Technology
- Issue: Vol 486, No 3 (2019)
- Pages: 380-383
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/13523
- DOI: https://doi.org/10.31857/S0869-56524863380-383
- ID: 13523
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Abstract
The oxidative modification of human hemoglobin Hb treated with ydrogen peroxide was investigated. The method of mass spectrometry were detected oxidized amino acid residues of the hemoglobin molecule: αTrp14, αTyr24, αArg31, αMet32, αTyr42, αHis45, αHis72, αMet76, αPro77, αLys90, αCys104, αTyr140, βHis2, βTrp15, βTrp37, βMet55, βCys93, βCys112, βTyr130, βLys144, βHis146. The antioxidant potential of the Hb molecule in the intracellular space and when it enters the blood plasma is discussed.
About the authors
A. D. Vasilyeva
Institute of Biochemical Physics of the Russian Academy of Sciences
Author for correspondence.
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
L. V. Yurina
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
A. E. Bugrova
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
M. I. Indeykina
Institute of Biochemical Physics of the Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991; 9, Institutskij, Dolgoprudny, Moscow region, 141701
D. Y. Azarova
Institute of Biochemical Physics of the Russian Academy of Sciences; Moscow State Academy of Veterinary Medicine and Biotechnology named after K.I. Skryabin
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991; 23, Academician Skryabin street , Moscow, 109472
A. V. Bychkova
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
K. I. Akzhigitova
Institute of Biochemical Physics of the Russian Academy of Sciences; Belinsky pedagogical Institute of Penza State University
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 11999; 37, Lermontova street, Penza, 440026
A. S. Kononikhin
Institute of Biochemical Physics of the Russian Academy of Sciences; Talrose Institute for EnergyProblems of Chemical Physics of the Russian Academy of Sciences; Moscow Institute of Physics and Technology
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991; 38-2, Leninsky Prospekt, Moscow, 119334; 9, Institutskij, Dolgoprudny, Moscow region, 141701
E. N. Nikolaev
Institute of Biochemical Physics of the Russian Academy of Sciences; Talrose Institute for EnergyProblems of Chemical Physics of the Russian Academy of Sciences; Skolkovo Institute of Science and Technology
Email: ms.kadaver@mail.ru
Corresponding Member of the Russian Academy of Sciences
Russian Federation, 4, Kosygina street, Moscow, 119991; 38-2, Leninsky Prospekt, Moscow, 119334;3, Nobelya street, Moscow, 143026M. A. Rosenfeld
Institute of Biochemical Physics of the Russian Academy of Sciences
Email: ms.kadaver@mail.ru
Russian Federation, 4, Kosygina street, Moscow, 119991
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