Email this article Changes in the regulatory T-lymphocyte counts in HIV-infected patients with a discordant response to antiretroviral therapy
- Authors: Saidakova E.V.1, Shmagel K.V.1, Shmagel N.G.1, Korolevskaya L.B.1, Chereshnev V.A.1,2
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Affiliations:
- Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
- Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
- Issue: Vol 487, No 5 (2019)
- Pages: 584-587
- Section: Cell biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/15913
- DOI: https://doi.org/10.31857/S0869-56524875584-587
- ID: 15913
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Abstract
We examined HIV‑infected patients with different efficiency of immune system restoration during the course of antiretroviral therapy. The study showed that against the background of low CD4+ T‑cell counts, subject with a discordant immunologic response (patients with less than 350 CD4+ T‑cells per µl of blood after more than two years of treatment) develop a regulatory CD4+ T‑cell (Treg) deficiency. Furthermore, in these patients, the immunodeficiency is accompanied by an increase in the Treg frequency. Accumulation of regulatory T‑cells in the blood of HIV‑infected subjects with discordant response to the treatment indicates a high viability of this T‑cell subset.
About the authors
E. V. Saidakova
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Author for correspondence.
Email: radimira@list.ru
Russian Federation, 13a, Lenina street, Perm, 614990
K. V. Shmagel
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, 13a, Lenina street, Perm, 614990
N. G. Shmagel
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, 13a, Lenina street, Perm, 614990
L. B. Korolevskaya
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences
Email: radimira@list.ru
Russian Federation, 13a, Lenina street, Perm, 614990
V. A. Chereshnev
Institute of Ecology and Genetics of Microorganisms, Ural Branch of the Russian Academy of Sciences; Institute of Immunology and Physiology, Ural Branch of Russian Academy of Sciences
Email: radimira@list.ru
Academician of the Russian Academy of Sciences
Russian Federation, 13a, Lenina street, Perm, 614990; 106, Pervomayskaya street, Yekaterinburg, 620049References
- Battegay M., Nüesch R., Hirschel B., Kaufmann G. R. The Lancet Infectious Diseases. 2006. V. 6. P. 280-287.
- Baker J.V., Peng G., Rapkin J., et al. // AIDS. 2008. V. 22. P. 841-848.
- Lapadula G., Cozzi-Lepri A., Marchetti G., et al. // AIDS. 2013. V. 27. P. 769-779.
- Piconi S., Trabattoni D., Gori A., et al. // AIDS. 2010. V. 24. P. 1991-2000.
- Marchetti G., Gori A., Casabianca A., et al. // AIDS. 2006. V. 20. P. 1727-1736.
- Hunt P.W., Martin J. N., Sinclair E., et al. // J. Infect. Dis. 2003. V. 187. P. 1534-1543.
- Sakaguchi S. // Annu. Rev. Immunol. 2004. V. 22. P. 531-562.
- Eggena M.P., Barugahare B., Jones N., et al. // J. Immunol. 2005. V. 174. P. 4407-4414.
- Moreno-Fernandez M.E., Zapata W., Blackard J. T., Franchini G., Chougnet C. A. // J. Virol. 2009. V. 83. P. 12 925-12 933.
- Oswald-Richter K., Grill S. M., Shariat N., et al. // PLoS Biol. 2004. V. 2. P. E198.
- Presicce P., Orsborn K., King E., et al. // PLoS One. 2011. V. 6. P. e28118.
- Nobrega C., Horta A., Coutinho-Teixeira V., et al. // AIDS. 2016. V. 30. P. 1175-1186.
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