Sigma-1 receptor agonist amitriptyline inhibits store-dependent Ca2+ entry in macrophages

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Abstract


Using Fura-2AM microfluorimetry we have shown for the first time that sigma-1 receptor agonist - tricyclic antidepressant amitriptyline - significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.


About the authors

Z. I. Krutetskaya

Saint-Petersburg State University

Author for correspondence.
Email: z.krutetskaya@spbu.ru

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034

L. S. Milenina

Saint-Petersburg State University

Email: z.krutetskaya@spbu.ru

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034

V. G. Antonov

Saint-Petersburg State University

Email: z.krutetskaya@spbu.ru

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034

A. D. Nozdrachev

Saint-Petersburg State University; Pavlov Institute of Physiology of the Russian Academy of Sciences

Email: a.d.nozdrachev@mail.ru

Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034; 6, Makarova street, St.Petersburg, 199034

Academician of the Russian Academy of Sciences

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