Potassium salt of fullerenylpenta-N-dihydroxytyrosine effects on type 2 diabetes mellitus therapeutic targets

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Abstract

It was shown for the first time that pentaamino acid derivative of fullerene C60 (potassium salt of fullerenylpenta-N-dihydroxytyrosine) effects on three targets of type 2 diabetes mellitus. It competitively inhibits the enzymes aldose reductase and sorbitol dehydrogenase and also exhibits antiglycation effect on bovine serum albumin. The enzymes inhibition constants were calculated.

About the authors

Yu. V. Soldatova

Institute of Problem of Chemical Physics of the Russian Academy of Science; Moscow Region State University

Author for correspondence.
Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 24, Very Voloshinoy street, Mytishi, 141014

R. A. Kotelnikova

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. V. Zhilenkov

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

I. I. Faingold

Institute of Problem of Chemical Physics of the Russian Academy of Science; Moscow Region State University

Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 24, Very Voloshinoy street, Mytishi, 141014

P. A. Troshin

Institute of Problem of Chemical Physics of the Russian Academy of Science; Skolkovo Institute of Science and Technology

Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 3, Nobelya street, Moscow, 143026

M. A. Kozlova

Moscow Region State University

Email: soldatovayv@gmail.com
Russian Federation, 24, Very Voloshinoy street, Mytishi, 141014

D. A. Areshidze

Institute of Problem of Chemical Physics of the Russian Academy of Science; Moscow Region State University

Email: soldatovayv@gmail.com
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 24, Very Voloshinoy street, Mytishi, 141014

S. M. Aldoshin

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: soldatovayv@gmail.com

Academician of the Russian Academy of Science

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

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