Email this article The novel element in the mechanism of endogenous regulation of depressive-like states
- Authors: Garibova T.L.1, Gudasheva T.A.1, Seredenin S.B.1
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Affiliations:
- Zakusov Research Institute of Pharmacology
- Issue: Vol 488, No 4 (2019)
- Pages: 443-445
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/17694
- DOI: https://doi.org/10.31857/S0869-56524884443-445
- ID: 17694
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Abstract
It was shown previously that cyclo-prolylglycine, an endogenous neuropeptide, is a positive AMPA receptor modulator and is able to increase the content of BDNF in neurons. In the present work it was shown that cyclo-prolylglycine at a dose of 1 mg/kg with subchronic intraperitoneal administration reduces the time of animal immobility to passive control, from 167.6 to 83.6 s on the 12th day of the experiment using the model of learned helplessness in rats. That indicates the presence of antidepressant-like activity. The results of the study allow us to consider that cyclo-prolylglycine is a link in the physiological regulation of a depressive-like state.
About the authors
T. L. Garibova
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Russian Federation, 8, Baltiyskaya str., Moscow, 125315
T. A. Gudasheva
Zakusov Research Institute of Pharmacology
Author for correspondence.
Email: tata-sosnovka@mail.ru
Corresponding Member of the Russian Academy of Sciences
Russian Federation, 8, Baltiyskaya str., Moscow, 125315S. B. Seredenin
Zakusov Research Institute of Pharmacology
Email: tata-sosnovka@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 8, Baltiyskaya str., Moscow, 125315References
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