Email this article Immunoistochemical and morphological study of periodont tissues when predicting the results of dental implantation in patients with chronic parodontitis
- Authors: Kulakov A.A.1,2, Kogan E.A.1, Brailovskaya T.V.1,2, Vedyaeva A.P.1,2, Zharkov N.V.1
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Affiliations:
- The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
- Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of Russia
- Issue: Vol 488, No 4 (2019)
- Pages: 452-456
- Section: Cell biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/17698
- DOI: https://doi.org/10.31857/S0869-56524884452-456
- ID: 17698
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Abstract
A morphological and immunohistochemical study of 24 gums biopsies was conducted in 19 patients aged 35-60 years with a diagnosis of partial secondary edentulous, chronic generalized periodontitis of moderate and severe degree (14 patients), and also without pathological changes in the periodontal disease (5 patients), who underwent dental implantation. Immunohistochemical reactions with antibodies to Ki-67, VEGF, SMA were performed on serial paraffin sections. It has been established that chronic periodontitis is characterized by a higher proliferative activity of the epithelium, which reflects its hyperplastic changes, as well as a lower content of SMA positive cells and the practical absence of the formation of privascular couplings from SMA-positive cells that are associated in tissues with “growth zones”, which indirectly indicates reduced tissue regenerative capacity. Therefore, in the case of the operation of dental implantation requires additional treatment aimed at anti-inflammatory and pro-regenerative effects.
Keywords
About the authors
A. A. Kulakov
The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation; Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of Russia
Email: avedyaeva@yandex.ru
Academician of the Russian Academy of Sciences
Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; 16, Timur Frunze str., Moscow, 119034E. A. Kogan
The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Email: avedyaeva@yandex.ru
Russian Federation, 8-2, Trubetskaya street, Moscow, 119992
T. V. Brailovskaya
The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation; Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of Russia
Email: avedyaeva@yandex.ru
Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; 16, Timur Frunze str., Moscow, 119034
A. P. Vedyaeva
The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation; Central Research Institute of Dentistry and Maxillofacial Surgery of the Ministry of Health of Russia
Author for correspondence.
Email: avedyaeva@yandex.ru
Russian Federation, 8-2, Trubetskaya street, Moscow, 119992; 16, Timur Frunze str., Moscow, 119034
N. V. Zharkov
The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation
Email: avedyaeva@yandex.ru
Russian Federation, 8-2, Trubetskaya street, Moscow, 119992
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