Email this article Dimeric disintegrins from the Vipera ursinii steppe viper venom
- Authors: Kryukova E.V.1, Potapenko A.S.1, Andreeva T.V.1, Ivanov I.A.1, Ryabinin V.V.1, Ziganshin R.H.1, Starkov V.G.1, Ayvazyan N.M.2, Tsetlin V.I.1, Utkin Y.N.1
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Affiliations:
- Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
- L.Orbeli Institute of Physiology, National Academy of Sciences of Armenia
- Issue: Vol 488, No 5 (2019)
- Pages: 567-570
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/17832
- DOI: https://doi.org/10.31857/S0869-56524885567-570
- ID: 17832
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Abstract
Four dimeric disintegrins were isolated from the venom of the steppe viper V. ursinii using liquid chromatography. Disintegrins prevented adhesion of MCF7 cells to fibronectin, which indicates their interaction with integrin receptors of the αVβ1 type. According to mass spectrometry data, the molar masses of disintegrins are about 14 kDa.
Keywords
About the authors
E. V. Kryukova
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Author for correspondence.
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
A. S. Potapenko
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
T. V. Andreeva
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
I. A. Ivanov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
V. V. Ryabinin
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
R. H. Ziganshin
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
V. G. Starkov
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
N. M. Ayvazyan
L.Orbeli Institute of Physiology, National Academy of Sciences of Armenia
Email: evkr@mail.ru
Armenia, 0028, Yerevan, Orbeli Bros. str., 22
V. I. Tsetlin
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Corresponding Member of the Russian Academy of Sciences
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997Yu. N. Utkin
Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences
Email: evkr@mail.ru
Russian Federation, 16/10, Miklukho-Maklaya Street, Moscow, 117997
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