Antioxidant activity of tetra nitrosyl iron complex with thiosulfate ligands and its effect on catalytic activity of mitochondrial enzymes in vitro

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Abstract


The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) in the mouse brain homogenates in vitro were also studied. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes: cytochrome c oxidase and monoamine oxidase A has been studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in the brain mitochondria isolated from animals in vitro.


About the authors

I. I. Faingold

Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University

Author for correspondence.
Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24

R. A. Kotelnikova

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. V. Smolina

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

D. A. Poletaeva

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

Yu. V. Soldatova

Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24

O. V. Pokidova

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. P. Sadkov

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

N. A. Sanina

Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University; Lomonosov Moscow State University

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24; 1, Leninskie gory, Moscow, 119991

S. M. Aldoshin

Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University

Email: ifaingold@mail.ru

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991

Academician of the Russian Academy of Science

References

  1. Rosselli M., Keller P.J., Dubey R.K. // Hum. Reprod. Update. 1998. V. 4. № 1. P. 3-24.
  2. Nitric Oxide / ed. Ignarro L. N. Y. Academic Press,2000. 1017 p.
  3. Fung H.L. // Annu. Rev. Pharmacol. Toxicol. 2004. V. 44. P. 67-85.
  4. Санина Н.А., Алдошин С.М., Руднева Т.Н. и др. // Координац. химия. 2005. V. 31. № 5. P. 323-328.
  5. Татьяненко Л.В., Котельников А.И., Добро-хо-това О.В. и др. // Хим.-фармац. жур. 2009. V. 43. № 9. P. 45-49.
  6. Halliwell B. // Nutr. Rev. 2012. V. 70. № 5. P. 257-265.
  7. Котельникова Р.А., Григорьев В.В., Смолина А.В. и др. // Изв. АН. Сер. хим. 2014. № 10. P. 2375-2382.
  8. Карякин Ю.В., Ангелов И.И. Чистые химические вещества. Химия. 1974. 408 p.
  9. Di Meo S., Venditti P., Piro M.C., De Leo T. // Arch. Physiol. Biochem. 1995. V. 103. № 2. P. 187-195.
  10. Bortolato M., Chen K., Shih J.C. // Adv. Drug Deliv. Rev. 2008. V. 60. № 13/14. P. 1527-1533.
  11. Mialet-Perez J., Bianchi P., Kunduzova O., et al. // J. Neural Transm. 2007. V. 114. № 6. P. 823-827.
  12. Corbineau S., Breton M., Mialet-Perez J., et al. // Int. J. Cardiol. 2017. V. 247. P. 1-6.
  13. Taylor C.T., Moncada S. // Arterioscler. Thromb. Vasc. Biol. 2010. V. 30, № 4. P. 643-647.
  14. Trounce I.A., Kim Y.L., Jun A.S., et al. // Methods Enzymol. 1996. V. 264. P. 484-509.

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