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Antioxidant activity of tetra nitrosyl iron complex with thiosulfate ligands and its effect on catalytic activity of mitochondrial enzymes in vitro
- Authors: Faingold I.I. 1,2, Kotelnikova R.A. 1, Smolina A.V. 1, Poletaeva D.A. 1, Soldatova Y.V. 1,2, Pokidova O.V. 1, Sadkov A.P. 1, Sanina N.A. 1,2,3, Aldoshin S.M. 1,3
- Affiliations:
- Institute of Problem of Chemical Physics of the Russian Academy of Science
- Medicinal Chemistry Research and Education Center, Moscow region State University
- Lomonosov Moscow State University
- Issue: Vol 488, No 5 (2019)
- Pages: 571-575
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/17833
- DOI: https://doi.org/10.31857/S0869-56524885571-575
- Cite item
Abstract
The antioxidant and antiradical properties of the tetra nitrosyl iron complex with thiosulfate ligands (TNIC) in the mouse brain homogenates in vitro were also studied. It was found for the first time that TNIC is an effective antioxidant. The effect of TNIC on the catalytic activity of mitochondrial enzymes: cytochrome c oxidase and monoamine oxidase A has been studied. It was shown for the first time that TNIC is an inhibitor of the catalytic activity of cytochrome c oxidase and monoamine oxidase A in the brain mitochondria isolated from animals in vitro.
About the authors
I. I. Faingold
Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University
Author for correspondence.
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24
R. A. Kotelnikova
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
A. V. Smolina
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
D. A. Poletaeva
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
Yu. V. Soldatova
Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24
O. V. Pokidova
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
A. P. Sadkov
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
N. A. Sanina
Institute of Problem of Chemical Physics of the Russian Academy of Science; Medicinal Chemistry Research and Education Center, Moscow region State University; Lomonosov Moscow State University
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 141014, Moscow region, Mytishchi, Vera Voloshina str., 24; 1, Leninskie gory, Moscow, 119991
S. M. Aldoshin
Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University
Email: ifaingold@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991
Academician of the Russian Academy of Science
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