Email this article Resistance of THP-1 leukemia cells infected with cytomegalovirus to anti-tumor antibiotic doxorubicin and restoration the sensitivity by inhibitors of the molecular way PI3K/AKT/mTOR
- Authors: Chernoryzh Y.Y.1, Fedorova N.E.1, Yurlov K.I.1, Simonov R.A.1, Kornev A.B.2, Karpov D.S.3, Zakirova N.F.3, Ivanov A.V.3, Kushch A.A.1, Gintsburg A.L.1,4
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Affiliations:
- Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
- Institute of Problem of Chemical Physics of the Russian Academy of Science
- Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
- The First Sechenov Moscow State Medical University under the Ministry of Health of the Russian Federation
- Issue: Vol 489, No 4 (2019)
- Pages: 433-437
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/18704
- DOI: https://doi.org/10.31857/S0869-56524894433-437
- ID: 18704
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Abstract
Results obtained showed that infection with HCMV prevented the death of THP‑1 cells treated with DOX in both active and latent forms of infection. In the presence of mTOR inhibitors (rapamycin and Torin2), the sensitivity of the infected cells to DOX was restored. Rapamycin inhibited the expression of HCMV protein IE1-p72 and increased sensitivity to DOX. Molecular targets for the creation of new drugs for the treatment of leukemia in patients infected with HCMV have been determined.
About the authors
Ya. Yu. Chernoryzh
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Russian Federation, 18, Gamalei street, Moscow, 123098
N. E. Fedorova
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Russian Federation, 18, Gamalei street, Moscow, 123098
K. I. Yurlov
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Russian Federation, 18, Gamalei street, Moscow, 123098
R. A. Simonov
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Russian Federation, 18, Gamalei street, Moscow, 123098
A. B. Kornev
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: vitallku@mail.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
D. S. Karpov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: vitallku@mail.ru
Russian Federation, 32, Vavilov street, Moscow, 119991
N. F. Zakirova
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: vitallku@mail.ru
Russian Federation, 32, Vavilov street, Moscow, 119991
A. V. Ivanov
Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences
Email: vitallku@mail.ru
Russian Federation, 32, Vavilov street, Moscow, 119991
A. A. Kushch
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation
Author for correspondence.
Email: vitallku@mail.ru
Russian Federation, 18, Gamalei street, Moscow, 123098
A. L. Gintsburg
Gamaleya National Research Center for Epidemiology and Microbiology, the Ministry of Health of the Russian Federation; The First Sechenov Moscow State Medical University under the Ministry of Health of the Russian Federation
Email: vitallku@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 18, Gamalei street, Moscow, 123098; 8-2, Trubetskaya street, Moscow, 119992References
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