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Anti-cancer activity of dinitrosyl iron complex (no donor) on the multiple myeloma cells
- Authors: Akentieva N.P.1,2, Sanina N.A.1,3, Prichodchenko T.R.1, Gizatullin A.R.1, Shkondina N.I.1, Shushanov S.S.4, Stupina T.S.1,2, Aldoshin S.M.1,3
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Affiliations:
- Institute of Problem of Chemical Physics of the Russian Academy of Science
- Scientific Center in Chernogolovka of the Russian Academy of Sciences
- Lomonosov Moscow State University
- Federal State Budgetary Scientific Institution «N.N.Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation
- Issue: Vol 486, No 6 (2019)
- Pages: 742-747
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/14526
- DOI: https://doi.org/10.31857/S0869-56524866742-747
- ID: 14526
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Abstract
The results of a study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donor) on the cell viability of multiple myeloma cells are presented. It has been shown that DNIC7 decreased cell viability and inhibited the proliferation of cells of multiple myeloma, i.e. possesses cytotoxic properties. Fluorescent analysis revealed that the DNIC7 compound lowers the level of intracellular glutathione and increases the level of reactive oxygen species in cells of multiple myeloma. It is assumed that DNIC7 has the therapeutic potential for the treatment of cancer.
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About the authors
N. P. Akentieva
Institute of Problem of Chemical Physics of the Russian Academy of Science; Scientific Center in Chernogolovka of the Russian Academy of Sciences
Author for correspondence.
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 8, Institutsky prospect, Chernogolovka, Moscow region, 142432
N. A. Sanina
Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991
T. R. Prichodchenko
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
A. R. Gizatullin
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
N. I. Shkondina
Institute of Problem of Chemical Physics of the Russian Academy of Science
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432
S. S. Shushanov
Federal State Budgetary Scientific Institution «N.N.Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation
Email: na_aken@icp.ac.ru
Russian Federation, 24, Kashirskoye sh., Moscow, 115478
T. S. Stupina
Institute of Problem of Chemical Physics of the Russian Academy of Science; Scientific Center in Chernogolovka of the Russian Academy of Sciences
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 8, Institutsky prospect, Chernogolovka, Moscow region, 142432
S. M. Aldoshin
Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University
Email: na_aken@icp.ac.ru
Academician Russian Academy of Sciences
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; Lomonosov Moscow State UniversityReferences
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