Anti-cancer activity of dinitrosyl iron complex (no donor) on the multiple myeloma cells

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Abstract

The results of a study of the effect of a mononuclear dinitrosyl iron complex (DNIC7) with functional sulfur-containing ligands (NO donor) on the cell viability of multiple myeloma cells are presented. It has been shown that DNIC7 decreased cell viability and inhibited the proliferation of cells of multiple myeloma, i.e. possesses cytotoxic properties. Fluorescent analysis revealed that the DNIC7 compound lowers the level of intracellular glutathione and increases the level of reactive oxygen species in cells of multiple myeloma. It is assumed that DNIC7 has the therapeutic potential for the treatment of cancer.

About the authors

N. P. Akentieva

Institute of Problem of Chemical Physics of the Russian Academy of Science; Scientific Center in Chernogolovka of the Russian Academy of Sciences

Author for correspondence.
Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 8, Institutsky prospect, Chernogolovka, Moscow region, 142432

N. A. Sanina

Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University

Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 1, Leninskie gory, Moscow, 119991

T. R. Prichodchenko

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

A. R. Gizatullin

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

N. I. Shkondina

Institute of Problem of Chemical Physics of the Russian Academy of Science

Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432

S. S. Shushanov

Federal State Budgetary Scientific Institution «N.N.Blokhin Russian Cancer Research Center» of the Ministry of Health of the Russian Federation

Email: na_aken@icp.ac.ru
Russian Federation, 24, Kashirskoye sh., Moscow, 115478

T. S. Stupina

Institute of Problem of Chemical Physics of the Russian Academy of Science; Scientific Center in Chernogolovka of the Russian Academy of Sciences

Email: na_aken@icp.ac.ru
Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; 8, Institutsky prospect, Chernogolovka, Moscow region, 142432

S. M. Aldoshin

Institute of Problem of Chemical Physics of the Russian Academy of Science; Lomonosov Moscow State University

Email: na_aken@icp.ac.ru

Academician Russian Academy of Sciences

Russian Federation, 1, Acad. Semenov av., Chernogolovka, Moscow region, 142432; Lomonosov Moscow State University

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