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Sigma-1 receptor agonist amitriptyline inhibits store-dependent Ca2+ entry in macrophages
- Authors: Krutetskaya Z.I.1, Milenina L.S.1, Antonov V.G.1, Nozdrachev A.D.1,2
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Affiliations:
- Saint-Petersburg State University
- Pavlov Institute of Physiology of the Russian Academy of Sciences
- Issue: Vol 488, No 2 (2019)
- Pages: 221-224
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/16113
- DOI: https://doi.org/10.31857/S0869-56524882221-224
- ID: 16113
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Abstract
Using Fura-2AM microfluorimetry we have shown for the first time that sigma-1 receptor agonist - tricyclic antidepressant amitriptyline - significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.
About the authors
Z. I. Krutetskaya
Saint-Petersburg State University
Author for correspondence.
Email: z.krutetskaya@spbu.ru
Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034
L. S. Milenina
Saint-Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034
V. G. Antonov
Saint-Petersburg State University
Email: z.krutetskaya@spbu.ru
Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034
A. D. Nozdrachev
Saint-Petersburg State University; Pavlov Institute of Physiology of the Russian Academy of Sciences
Email: a.d.nozdrachev@mail.ru
Academician of the Russian Academy of Sciences
Russian Federation, 7/9, Universitetskaya embankment, Saint-Petersburg, 199034; 6, Makarova street, St.Petersburg, 199034References
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