Email this article 
Magnificamide is a new effective mammalian a-amylase inhibitor
- Authors: Sintsova O.V.1, Leychenko E.V.1, Gladkikh I.N.1, Kalinovskii A.P.1,2, Monastyrnaya M.M.1, Kozlovskaya E.P.1
-
Affiliations:
- G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
- Far Eastern Federal University
- Issue: Vol 489, No 4 (2019)
- Pages: 429-432
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/18703
- DOI: https://doi.org/10.31857/S0869-56524894429-432
- ID: 18703
Cite item
Full Text
Abstract
Recombinant analog of sea anemone Heteractis magnifica peptide was obtained and kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than a medical drug acarbose (PrecoseTM or GlucobayTM). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.
Keywords
About the authors
O. V. Sintsova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Author for correspondence.
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
E. V. Leychenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
I. N. Gladkikh
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
A. P. Kalinovskii
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences; Far Eastern Federal University
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022; 8, Sukhanova St., Vladivostok, Russia, 690950
M. M. Monastyrnaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
E. P. Kozlovskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
References
- Alam U., Asghar O., Azmi S. // Handbook. Clin. Neurol. 2014. V. 126. P. 211-222.
- Pandey A., Chawla S., Guchhait P. // IUBMB Life. 2015. V. 67. P. 506-513.
- Aye T., Levitsky L.L. // Curr. Opin. Pediatr. 2003. V. 15. P. 411-415.
- Temneanun O.R., Trandafir L.M., Purcarea M.R. // J. Med. Life. 2016. V. 9. P. 235-239.
- Scheen A.J. // Drugs. 2003. V. 63. P. 933-951.
- Chiasson J.-L., Josse R.G., Gomis R., et al. // Lancet. 2002. V. 359. P. 2072-2077.
- Wu H., Liu J., Lou Q., et al. // Medicine (Baltimore). 2017. V. 96. P. 7533.
- Fosgerau K., Hoffmann T. // Drug Discov. Today. 2015. V. 20. P. 122-128.
- Sintsova O., Gladkikh I., Chausova V., et al. // J. Proteomics. 2018. V. 173. P. 12-21.
- Sintsova O.V., Monastyrnaya M.M., Pislyagin E.A., et al. // Russ. J. Bioorganic Chem. 2015. V. 41. P. 590-596.
- Monastyrnaya M., Peigneur S., Zelepuga E., et al. // Mar. Drugs. 2016. V. 14. P. 229.
- Morrison J.F. // Biochim. Biophys. Acta-Enzymol. 1969. V. 185. P. 269-286.
- Yoon S.H., Robyt J.F. // Carbohydr. Res. 2003. V. 338. P. 1969-1980.
Supplementary files
