Email this article Magnificamide is a new effective mammalian a-amylase inhibitor
- Authors: Sintsova O.V.1, Leychenko E.V.1, Gladkikh I.N.1, Kalinovskii A.P.1,2, Monastyrnaya M.M.1, Kozlovskaya E.P.1
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Affiliations:
- G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
- Far Eastern Federal University
- Issue: Vol 489, No 4 (2019)
- Pages: 429-432
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/18703
- DOI: https://doi.org/10.31857/S0869-56524894429-432
- ID: 18703
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Abstract
Recombinant analog of sea anemone Heteractis magnifica peptide was obtained and kinetic parameters of its interaction with mammalian α-amylases were determined. Magnificamide inhibits α-amylases significantly stronger than a medical drug acarbose (PrecoseTM or GlucobayTM). Magnificamide is assumed to find application as a drug for prevention and treatment of metabolic disorders and type 2 diabetes mellitus.
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About the authors
O. V. Sintsova
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Author for correspondence.
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
E. V. Leychenko
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
I. N. Gladkikh
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
A. P. Kalinovskii
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences; Far Eastern Federal University
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022; 8, Sukhanova St., Vladivostok, Russia, 690950
M. M. Monastyrnaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
E. P. Kozlovskaya
G.B. Elyakov Pacific Institute of Bioorganic Chemistry, Far Eastern Branch of Russian Academy of Sciences
Email: sintsova0@gmail.com
Russian Federation, 159, 100-let Vladivostoku prospekt, Vladivostok, 690022
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