Email this article Study оf dCTCF insulator activity in Drosophila melanogaster model systems
- Authors: Postika N.E.1, Ivlieva T.A.1, Georgiev P.G.1, Kyrchanova O.V.1
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Affiliations:
- Institute of Gene Biology of the Russian Academy of Sciences
- Issue: Vol 486, No 2 (2019)
- Pages: 262-266
- Section: Biochemistry, biophysics, molecular biology
- URL: https://journals.eco-vector.com/0869-5652/article/view/13454
- DOI: https://doi.org/10.31857/S0869-56524862262-266
- ID: 13454
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Abstract
Using Drosophila transgenic model systems, we have shown that the four binding sites for the architectural protein dCTCF themselves have no insulator activity. They cannot block enhancers and protect from Polycomb-dependent repression. The results suggest that in the known Drosophila insulators, the dCTCF protein functions in cooperation with other architectural proteins.
Keywords
About the authors
N. E. Postika
Institute of Gene Biology of the Russian Academy of Sciences
Author for correspondence.
Email: nk.postika@gmail.com
Russian Federation, 34/5, Vavilova street, Moscow, 119334
T. A. Ivlieva
Institute of Gene Biology of the Russian Academy of Sciences
Email: nk.postika@gmail.com
Russian Federation, 34/5, Vavilova street, Moscow, 119334
P. G. Georgiev
Institute of Gene Biology of the Russian Academy of Sciences
Email: nk.postika@gmail.com
Academician of the Russian Academy of Sciences
Russian Federation, 34/5, Vavilova street, Moscow, 119334O. V. Kyrchanova
Institute of Gene Biology of the Russian Academy of Sciences
Email: nk.postika@gmail.com
Russian Federation, 34/5, Vavilova street, Moscow, 119334
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