CORRELATION OF COGNITIVE DEFECTS AND AFFECTIVE DISORDERS WITH TESTOSTERONE AND ESTRADIOL LEVELS IN PATIENTS WITH CHRONIC CEREBRAL ISCHEMIA



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Abstract

There was investigated the correlation of sex hormones with cognitive defects and affective disorders in patients aged 46-76 years with chronic cerebral ischemia, with the presence of a peptic ulcer and postinfarction cardiosclerosis in their past medical history. We measured the blood testosterone level in men and the blood estradiol level in women. Study of differential role of steroids in cognitive sphere and emotional status revealed significant values of testosterone in men as distinct from women: it turned out to be involved in the pathogenic response mechanism to stress, in the development of cognitive and affective disorders.

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About the authors

Aleksandra V Shevchenko

Novosibirsk State Medical University

Email: av.shevchenko80@mail.ru
52, Krasniy Av., Novosibirsk, 630000

Tamara G Amstislavskaya

Institute of Physiology and Basic Medicine

Email: amstislavskaya@yandex.ru
4, Timakova Str., Novosibirsk, 630117

olga B Doronina

Novosibirsk State Medical University

52, Krasniy Av., Novosibirsk, 630000

Marina V Khrapova

Institute of Physiology and Basic Medicine

4, Timakova Str., Novosibirsk, 630117

Uriy V Ites

Institute of Experimental Veterinary of Siberia and the Far East

Email: ites_uv@ngs.ru
The industrial township of Krasnoobsk, the Novosibirsk district, the Novosibirsk region, 630501

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Copyright (c) 2015 Shevchenko A.V., Amstislavskaya T.G., Doronina o.B., Khrapova M.V., Ites U.V.

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