COMPLEX BEHAVIOR ALTERATIONS IN ANIMALS, WHICH UNDERWENT PERINATAL HYPOXIA OR EARLY LIFE STRESS



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Abstract

We have studied the development of complex behavior alterations in the rats subjected to perinatal hypoxia or early life stress. Animals with perinatal hypoxia or social early life stress induce alterations of complex forms of behavior such as dysfunction of social recognition. The development of early life stress shows rejection of the new food, emotional lability and anxiety, much earlier than in rats with perinatal hypoxia.

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About the authors

Natalya A Malinovskaya

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Julia A Uspenskaya

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Julia A Panina

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Victoria V Volkova

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Roman V Ryabokon

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Natalya V Kuvacheva

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Andrei V Morgun

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

Alla B Salmina

Krasnoyarsk state medical university named after V.F. Voino-Jasenetsky

Email: reg.kgmu@gmail.com
Research Institute of molecular medicine and pathobiochemistry, department of biological chemistry with the courses of medical, pharmaceutical and toxicological chemistry 660022, Кrasnoyarsk, Parttisan Zheleznyak str., 1

References

  1. Яузина Н.А., Комлева Ю.К., Салмина А.Б. и др. Современные экспериментальные модели депрессии // Биомедицина. 2013. № 1. С. 61-71.
  2. Яузина Н.А., Черепанов С.М., Комлева Ю.К. и др. Влияние стресса раннего периода жизни на поведение, нейрогенез и апоптоз клеток головного мозга крыс // Сибирское медицинское обозрение. 2013. № 5. С. 3-10.
  3. Boldrini M., Hen R., Underwood M.D. et al. Hippocampal angiogenesis and progenitor cell proliferation are increased with antidepressant use in major depression // Biol. Psychiatry. 2012. Vol. 72 (7). P. 562-571.
  4. Clancy B., Kersh B., Hyde J. et al. Web-based method for translating neurodevelopment from laboratory species to humans // Neuroinformatics. 2007. Vol. 5 (1). P. 79-94.
  5. Cohen R.A., Grieve S., Hoth K.F. et al. Early life stress and morphometry of the adult anterior cingulate cortex and caudate nuclei // Biol. Psychiatry. 2006. Vol. 59 (10). P. 975-982.
  6. Deacon R.M. Hyponeophagia: a measure of anxiety in the mouse // J. Vis. Exp. 2011. Vol. 17 (51). P. 1-4.
  7. Hanson J.L., Nacewicz B.M., Sutterer M.J. et al. Behavioral problems after early life stress: contributions of the hippocampus and amygdala // Biol Psychiatry. 2015. Vol. 77 (4). P. 314-323.
  8. Harrison E.L., Baune B.T. Modulation of early stress-induced neurobiological changes: a review of behavioural and pharmacological interventions in animal models // Transl. Psychiatry. 2014. Vol. 4. P. 1-18.
  9. Huang L.T. Early-life stress impacts the developing hippocampus and primes seizure occurrence: cellular, molecular, and epigenetic mechanisms // Front. Mol. Neurosci. 2014. Vol. 7. P. 1-15.
  10. Lajud N., Torner L. Early life stress and hippocampal neurogenesis in the neonate: sexual dimorphism, long term consequences and possible mediators // Front. Mol. Neurosci. 2015. Vol. 8. P. 1-10.
  11. Loi M., Koricka S., Lucassen P.J., Joëls M. Age- and sex-dependent effects of early life stress on hippocampal neurogenesis // Front Endocrinol (Lausanne). 2014. Vol. 5. P. 1-11.
  12. Marmendal M., Roman E., Eriksson C.J. et al. Maternal separation alters maternal care, but has minor effects on behavior and brain opioid peptides in adult offspring // Dev. Psychobiol. 2004. Vol. 45 (3). P. 140-152.
  13. McEwen B.S. Understanding the potency of stressful early life experiences on brain and body function // Metabolism. 2008. Vol. 57 (Suppl 2). P. S11-S15.
  14. Molet J., Maras P.M., Avishai-Eliner S., Baram T.Z. Naturalistic rodent models of chronic early-life stress // Dev. Psychobiol. 2014. Vol. 56 (8). P. 1675-1688.
  15. Nagdyman N., Kömen W., Ko H.K. et al. Early biochemical indicators of hypoxic-ischemic encephalopathy after birth asphyxia // Pediatr. Res. 2001. Vol. 49 (4). P. 502-506.
  16. Pechtel P., Pizzagalli D.A. Effects of early life stress on cognitive and affective function: an integrated review of human literature // Psychopharmacology (Berl). 2011. Vol. 214 (1). P. 55-70.
  17. Rice J.E., Vannucci R.C., Brierley J.B. The influence of immaturity on hypoxic-ischemic brain damage in the rat // Ann Neurol. 1981. Vol. 9 (2). P. 131-141.
  18. Uhelski M.L., Fuchs P.N. Maternal separation stress leads to enhanced emotional responses to noxious stimuli in adult rats // Behav. Brain Res. 2010. Vol. 212 (2). P. 208-212.
  19. Winslow JT. Mouse social recognition and preference // Curr. Protoc. Neurosci. 2003. Ch. 8.
  20. Zhang Q., Ding Y., Yao Y. et al. Creating rat model for hypoxic brain damage in neonates by oxygen deprivation // PLoS One. 2013. Vol. 8 (12). P. e83589.

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Copyright (c) 2015 Malinovskaya N.A., Uspenskaya J.A., Panina J.A., Volkova V.V., Ryabokon R.V., Kuvacheva N.V., Morgun A.V., Salmina A.B.

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