QUASI-PSYCHOTIC PHENOMENA IN AUTISM SPECTRUM DISORDERS



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Abstract

The article presents a diagnostically ambiguous clinical case of Yakov, a disabled person from childhood with "schizophrenia, childhood type, oligophrenia-like defect", who was repeatedly hospitalized in psychiatric hospitals from the age of three, and underwent antipsychotic therapy. During a special examination at the age of 23, the diagnosis of schizophrenia was not confirmed, since it did not correspond to the observed picture of psychopathological symptoms. It is stated that the diagnosis of "childhood schizophrenia" was given to the patient based on an erroneous interpretation of the observed behavioral disorders and symptoms of "emotional-volitional defect" - since childhood the boy was uncommunicative, unsociable, uninitiative, emotionless, was prone to committing "strange" acts, and there was a delay in mental and speech development. Later, the lag in intellectual and speech development was eliminated, but the "oddities" of behavior, communication difficulties, infantilism, as well as the tendency to fantasize and live in an imaginary reality remained. No distinct positive psychopathology was registered. When Yakov was examined at the age of 23, the dominant disorders remained communication difficulties, autism, and speech disorders specific to ASD, which allowed him to be diagnosed with autism spectrum disorder instead of schizophrenia. Attention was drawn to the fact that the symptoms detected in the patient, assessed as delusional, hallucinatory, as well as fragmented and incoherent thinking, could be interpreted as quasi-psychotic, associated with a violation of cognitive processing of information, and not as psychotic. An analysis of the literature was conducted and the attention of colleagues was drawn to the problem of overdiagnosis of schizophrenia and ignoring the possibility of similar symptoms as related to ASD.

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About the authors

Vladimir Davidovich Mendelevich

Kazan State Medical University, Kazan

Author for correspondence.
Email: mendelevich_vl@mail.ru
ORCID iD: 0000-0002-8476-6083
SPIN-code: 2302-2590
Scopus Author ID: 6602765981
https://kazangmu.ru/psychiatry/sotrudniki-kafedry

PhD, MD, Doctor of science (Medicine), Professor, Head of the department, Kazan State Medical University

Russian Federation, Kazan, Butlerova str., 49

Maria Kirillovna Nesterina

Kazan state medical university,

Email: mari.nesterina@mail.ru
ORCID iD: 0000-0001-6901-5903
SPIN-code: 5974-4048
Scopus Author ID: 57734765200

psychiatry and medical psychology department, resident

Turkey, Kazan, Butlerova str., 49

Veronika Nikolaevna Konovalova

Kazan state medical university

Email: veronikaveronika.3103@mail.ru
ORCID iD: 0000-0002-4043-0780
SPIN-code: 7579-4441
Scopus Author ID: 58793738500

assistent of professor department of psychiatry and medical psychology

Russian Federation, Kazan, Butlerova str., 49

References

  1. Ribolsi M., Fiori Nastro F., Pelle M. et al. Recognizing Psychosis in Autism Spectrum Disorder. // Front Psychiatry. 2022; vol. 28 (13): Pp. 768586. DOI: https://doi.org/10.3389/fpsyt.2022.
  2. Ivanovic I. Psychiatric Comorbidities in Children With ASD: Autism Centre Experience. // Front. Psychiatry. 2021; vol. 12: Pp. 673169. DOI: https://doi.org/10.3389/fpsyt.2021.673169.
  3. Mishma S.V.S., Shanmugan A. The prevalence of psychiatric and behavioral comorbid among autistic adults. Biotech. Res. Asia. 2024; 21 (2): DOI: https://doi.org/10.13005/bbra/3242.
  4. Chien Y.L., Wu C.S., Tsai H.J. The Comorbidity of Schizophrenia Spectrum and Mood Disorders in Autism Spectrum Disorder. // Autism Res. 2021; vol. 14 (3): Pp. 571-581. DOI: https://doi.org/10.1002/aur.2451.
  5. Barlattani T., D’Amelio C., Cavatassi A. et al. Autism spectrum disorders and psychiatric comorbidities: a narrative review. // Journal of Psychopathology 2023; vol. 29: Pp. 3-24. DOI: https://doi.org/10.36148/2284-0249-N281.
  6. Jutla A., Foss-Feig J., Veenstra-VanderWeele J. Autism spectrum disorder and schizophrenia: An updated conceptual review. // Autism Res. 2022; vol. 15 (3): Pp. 384-412. DOI: https://doi.org/10.1002/aur.2659.
  7. Blackshaw A.J., Kinderman P., Hare D.J., Hatton Ch. Theory of Mind, Causal Attribution and Paranoia in Asperger Syndrome. // Autism 2001; vol. 5: Pp. 147. DOI: https://doi.org/10.1177/1362361301005002005.
  8. Keller R., Bari S. Psychosis and ASD. Psychopathology in adolescents and adults with autism spectrum disorders. Springer Nature Switzeland AG. 2019: Pp. 51-65. DOI: https://doi.org/10.1007/978-3-030-26276-1_4.
  9. Keller R., Piedimonte A., Bianco F. et al. Diagnostic Characteristics of Psychosis and Autism Spectrum Disorder in Adolescence and Adulthood. A Case Series. // Autism Open Access. 2015; vol. 6: Pp. 159. DOI: https://doi.org/10.4172/2165-7890.1000159.
  10. Craiga J.S., Hattona Ch., Craigb F.B. et al. Persecutory beliefs, attributions and theory of mind: comparison of patients with paranoid delusions, Asperger’s syndrome and healthy controls. // Schizophrenia Research. 2004; vol. 69: Pp. 29-33. DOI: https://doi.org/10.1016/S0920-9964(03)00154-3
  11. Mazzone L., Ruta L., Reale L. Psychiatric comorbidities in Asperger syndrome and high functioning autism: diagnostic challenges. // Ann Gen Psychiatry. 2012; vol. 25 (11): Pp. 16. DOI: https://doi.org/10.1186/1744-859X-11-16.
  12. Varcin K.J., Herniman S.E., Lin A. et al. Occurrence of psychosis and bipolar disorder in adults with autism: A systematic review and meta-analysis. // Neuroscience and Biobehavioral Reviews. 2022; vol. 134: Pp. 104543. DOI: https://doi.org/10.1016/j.neubiorev.2022.104543.
  13. Chisholm K., Lin A., Abu-Akel A., Wood S.J. The association between autism and schizophrenia spectrum disorders: a review of eight alternate models of co-occurrence. // Neurosci Biobehav R. 2015; vol. 55: Pp. 173-183. DOI: https://doi.org/10.1016/j.neubiorev.2015.04.012.
  14. Perlman L. Adults with Asperger disorder misdiagnosed as schizophrenic. // Professional Psychology Research and Practice. 2000; vol. 31(2): Pp. 221-225; DOI: https://doi.org/10.1037//0735-7028.31.2.221.
  15. Trevisan D.A., Foss-Feig J.H., Naples A.J. et al. Autism Spectrum Disorder and Schizophrenia Are Better Differentiated by Positive Symptoms Than Negative Symptoms. // Front. Psychiatry. 2022; vol. 11: Pp. 548. DOI: https://doi.org/10.3389/fpsyt.2020.00548.
  16. Foss-Feig J.H., Lurie S., Hubert, M.F. Schizophrenia and other psychotic disorders in autism spectrum disorder. In S.W. White, B.B. Maddox, C.A. Mazefsky (Eds.), The Oxford handbook of autism and co-occurring psychiatric conditions (pp. 53–72). Oxford University Press.
  17. Nilsson M., Arnfred S., Carlsson J. et al. Self-Disorders in Asperger Syndrome Compared to Schizotypal Disorder: A Clinical Study. // Schizophrenia Bulletin. 2020; vol. 46 (1): Pp. 121–129. DOI: https://doi.org/10.1093/schbul/sbz036.
  18. Vaquerizo-Serrano J., Salazar de Pablo G., Singh J. et al. Autism Spectrum Disorder and Clinical High Risk for Psychosis: A Systematic Review and Meta-analysis. // Journal of Autism and Developmental Disorders. 2021, vol. 52 (4): Pp. 1568-1586. DOI: https://doi.org/10.1007/s10803-021-05046-0.
  19. Kincaid DL, Doris M, Shannon C, Mulholland C. What is the prevalence of autism spectrum disorder and ASD traits in psychosis? A systematic review. Psychiatry Res. 2017; vol. 250: Pp. 99-105. DOI: https://doi.org/10.1016/j.psychres.2017.01.017.
  20. Mammarella V., Monducci E., Maffucci A. et al. Assessment of Psychotic Risk in a Sample of Children and Adolescents with Autism Spectrum Disorder Compared to a Group of “Clinical High Risk” Patients: A Preliminary Study. // Children 2024; vol. 11: Pp. 372. DOI: https://doi.org/10.3390/children11030372.
  21. Licinio J., Wong M.L. Psychosis and autism spectrum disorder: a special issue of Molecular Psychiatry. // Mol Psychiatry. 2023; vol. 28 (5): Pp. 1830-1832. DOI: https://doi.org/10.1038/s41380-023-02250-5.
  22. Kiyono T., Morita M., Morishima R. et al. The Prevalence of Psychotic Experiences in Autism Spectrum Disorder and Autistic Traits: A Systematic Review and Meta-analysis. // Schizophrenia Bulletin Open. 2020; vol. 1 (1). DOI: https://doi.org/10.1093/schizbullopen/sgaa046.
  23. Мамохина У.А. Особенности речи при расстройствах аутистического спектра. // Аутизм и нарушения развития. 2017. Т. 15. № 3. С. 24-33. DOI: https://doi.org/10.17759/autdd.2017150304.
  24. Бородина Л.Г. Особенности психопатологии у взрослых с диагнозом расстройств аутистического спектра в детстве. Психиатрия. 2019;81(1):30–38. Borodina L.G. Osobennosti psihopatologii u vzroslyh s diagnozom rasstrojstv autisticheskogo spektra v detstve. Psihiatriya. 2019;81(1):30–38.
  25. Volkmar F.R., Klin A., Schultz R.T. et al. Asperger’s disorder. // American Journal of Psychiatry. 2020; vol. 157 (2): Pp.262-267; Brick, Martin (2024) "Not the Absentminded Professor: Autistic Experience and Representation in Academia," Ought: The Journal of Autistic Culture: Vol. 6: Iss. 1, Article 11. DOI: https://doi.org/10.970.
  26. Zhou H.Y., Yang H.X., Gong J.B. et al. Revisiting the overlap between autistic and schizotypal traits in the non-clinical population using meta-analysis and network analysis. // Schizophren Res. 2019; Vol. 212: Pp. 6-14.
  27. Moerloose S.D., Degraeve G., Smul C.D., Lemmens G. Autism spectrum disorder and schizophrenia: a challenging differential diagnosis. // Tijdschr Psychiatr. 2023; vol. 65 (1): Pp. 46-49.
  28. Bakken T.L., Eilertsen D.E., Smeby N.A. et al. The validity of disorganised behaviour as an indicator of psychosis in adults with autism and intellectual disability: A single case study. // Mental Health Aspects of Developmental Disabilities. 2009; vol. 12: Pp. 17–22.
  29. Bakken T.L. Behavioural equivalents of schizophrenia in people with intellectual disability and autism spectrum disorder. A selective review. //Int J Dev Disabil. 2021; vol. 67 (5): Pp. 310-317. DOI: https://doi.org/10.1080/20473869.2021.1925402.
  30. Bakken T.L., Helverschou S.B., Eilertsen D.E. et al. Psychiatric disorders in adolescents and adults with autism and intellectual disability: a representative study in one county in Norway. // Research in Developmental Disabilities. 2010; vol. 31 (6): Pp. 1669–1677. DOI: https://doi.org/10.1016/j.ridd.2010.04.009.
  31. West M.J., Somer E., Eigsti I.M. Immersive and maladaptive daydreaming and divergent thinking in autism spectrum disorders. // Imagin Cogn Pers. 2023; vol. 42 (4): Pp. 372-398. DOI: https://doi.org/10.1177/02762366221129819.
  32. Maat A., Therman S., Swaab H., Ziermans T. The Attenuated Psychosis Syndrome and Facial Affect Processing in Adolescents With and Without Autism. // Front. Psychiatry. 2020; vol. 11: Pp. 759. DOI: https://doi.org/10.3389/fpsyt.2020.00759.
  33. Менделевич В.Д. Гипердиагностика шизофрении как когнитивное искажение процесса познания клинической реальности // Неврологический вестник. 2023. Т. LV. Вып. 1. С. 5–14. DOI: https://doi.org/10.17816/nb160308. Mendelevich V.D. Giperdiagnostika shizofrenii kak kognitivnoe iskazhenie processa poznaniya klinicheskoj real'nosti // Nevrologicheskij vestnik. 2023. T. LV. Vyp. 1. S. 5–14. DOI: https://doi.org/10.17816/nb160308.

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