Vol XLIII, No 2 (2011)

For evaluating functional state of hematoenchephalic barrier 80 newborns of different gestational period with hemolytic disease of the newborns (HDN) and 30 infants with conjugated jaundice in the neonatal dynamics were examined. The function of hematoenchephalic barrier was defined by concentration of glyofibrillar acid protein and neurospecific enolase by polarization fluoroimmunoassay method. In the result of the newborns' follow-up there was revealed a precise correlation between their state and the level of neuro-specific proteins, being the index of penetration level of hematoencephalic barrier. In newborns with conjugated jaundice the expressed clinical manifestations are connected on one hand with the combined effect of acute and/or chronic hypoxia, and on the other hand with bilirubin toxic action, affecting hematoencephalic barrier, causing dismetabolic lesions of neurons.

There was studied titre of antibodies to the acetylcholine receptor in patients with myasthenia serum at pre-surgery stage. In patients with myasthenia with hyperplasia of thymus gland the average level of antibodiacetylcholine receptor exceeded 4 times the normal values and in patients with thymoma- 8 times. Level of antibodies to AChR did not correlate with the severity of myasthenia and myasthenia, combined with thymoma but tended to increase with the deterioration in specific cases. With a history of the disease more than a year there is a sharp increase in antibody levels in patients' serum, which leads to the progression of the disease.

Social characteristics and emotional state were investigated during in-vitro fertilization (IVF) cycles in 176 women with tube-peritoneal infertility. There was established a negative influence on pregnancy probability after in vitro fertilization of emotional state and social peculiarities of women: emotional lability, dependence on environment, demonstrativeness, attempts for responsibility avoiding, concentrated control of emotion manifestations and behavior, passivity, fatigue, absence of need for communication.

A comparative clinical, psycho-neurological and pathopsychological analysis of therapeutical effectiveness of the developed complex and combined reconstructive technologies of reduction of long-term effects of mild intracranial injuries in 106 combatants have been made. Possibilities of pharmacologic effect potentiation in the form of common magnetic therapy are shown.

To evaluate adaptive abilities of senior schoolchildren, suffering from diabetes mellitus, type I, there was performed a complex investigation of adaptation mechanisms at rest and during functional test. There was revealed a correlation between the obtained indices and manifestation of disadaptation syndrome.

Detailed description and justification of the maxillofacial markers of chronic alcoholism was done. There were shown the prevalence of chronic inflammatory periodontal diseases and chronic periodontitis, which during the period of abstinence in the background of the deep decline of the antimicrobial immune defense have a tendency to aggravate. There were presented data on peculiarities of gusto-reception and salivation in patients with alcohol dependence. It was proved the influence of substance abuse on the morphofunctional lingual status. To facilitate the identification of alcohol-depended pathology in providing dental care at the outpatient reception, a formalized map, unifying the diagnostic process, was offered.

There were studied and summarized results of theoretical and practical works of domestic and foreign neurology centers and manufacturing firms, producing implanted systems for detection and prophylaxis of epileptiform activity. Special attention was paid to neuroingeneric aspects of building such systems, particularly the systems of joint fields: neurology, system technique, micro-and-nanoelectronics. Conception of development of original neuromodullar system was offered.

It was shown that improvement of diagnostic methods and pharmacological development in the recent years caused a significant progress in the sphere of medical help to the epileptic patients. But at the same time an active usage of antiepileptic drugs has not also increased curability of epilepsy, but has also raised the risk of drug-associated complications. Unfavorable adverse reactions of antiepileptic drugs substantially increase cost of therapy, defalcate patient's trust to a doctor and worsen patient's quality life. One of unfavorable adverse reactions is antiepileptic drugs' ability to provoke or aggregate epileptic seizures in some paradox way.

The article describes psychodynamic conception of "ascending balance" adaptability. Results of longitude research of mothers' adaptability in maturation process of children with infantile cerebral paralysis are presented. Classification of adaptability types and information about psychological aspect of genesis of personal changes are presented. Main types of manifestation of mothers' adaptability on different stages of children maturation depending on subjective relations, mental experience and motivational-semantic relations are analyzed.