Flakozid - drug from the leaves of Phellodendron amurense Rupr., in treatment of diseases of the hepatobiliary system

Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access


The aim: to show the effectiveness of the drug Flakozid, which has a broad spectrum of antiviral action in combination with a hepato-protective effect, in the treatment of diseases of the hepatobiliary system. Material and Methods. The analysis of the effectiveness of the drug has been carried out based on the results of clinical studies of Flakozid, presented by Russian clinical institutions. Results. With chronic hepatitis and cirrhosis of the liver, unconjugated hyperbilirubinemia and fatty liver, the use of oral Flakozid in daily doses of 0.3-0.6 g for 25-45 days has led to an improvement in the general condition of patients, reduction of pain in the right hypochondrium, reduction of dyspeptic disorders, reduce the effects of asthenia, increase physical and intellectual performance, improve appetite. Noted a decrease in the level of total bilirubin and the normalization of the level of ALAT, ASAT and alkaline phosphatase. According to cholecystography, the concentration and contractility of the gallbladder improved. In terms of the severity of the therapeutic effect, Flakozid was not inferior to Silibour and Karsil, and in some indicators (improvement in motility of the gallbladder and biliary tract) markedly exceeded them. Conclusions. According to the results of clinical studies, it has been established that treatment of Flakozid has improved the functional state of the liver, reducing the syndrome of cytolysis and cholestasis. Flakozid has recommended in clinical practice in the complex treatment of diseases of the hepatobiliary system, such as CAG, chronic persistent hepatitis, chronic stoneless cholecystitis at the stage of subcompensation and decompensation.

Full Text

Restricted Access

About the authors

V. V Bortnikova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: bortnikova.v@yandex.ru

V. V Karabaeva

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: vera-karabaeva@rambler.ru

L. V Krepkova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: krepkowa2011@yandex.ru

G. F Sidelnikova

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: gal.fil@mail.ru

P. G Mizina

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: mizina-pg@yandex.ru

O. N Karabaeva

Moscow State University of Medicine and Dentistry named after A.I. Evdokimov

Email: vera-karabaeva@rambler.ru


  1. Гастроэнтерология: Справоч. издание / Под ред. И.Н. Денисова. М.: Эксмо. 2010. 558 с.
  2. Гастроэнтерология. Национальное руководство: Краткое издание / Под ред. В.Т. Ивашкина, Т.Л. Лапиной. М.: ГЭОТАР-Медиа. 2015. 480 с.
  3. Фатеева Т.В., Дерябин П.Г., Бортникова В.В., Крепкова Л.В., Мизина П.Г. Активность флакозида при вирусном гепатите С в экспериментах in vitro. Бюллетень экспериментальной биологии и медицины. 2019. № 4. С. 463-466.
  4. Бортникова В.В., Крепкова Л.В. Экспериментальное токсикологическое изучение противовирусного фитопрепарата флакозид. Вестник Российского университета дружбы народов (РУДН). 2008. № 7. С. 92-95.
  5. Вичканова С.А., Багинская А.И., Шипулина Л.Д. Колхир В.К., Бортникова В.В., Городнюк Т.И. Флакозид - эффективное растительное средство для лечения гепатитов вирусной и не вирусной этиологии, а также вирусных поражений кожи. Сб. науч. трудов ВИЛАР: химия, технология, медицина. 2000. С. 316-323.
  6. Вичканова С.А., Колхир В.К., Сокольская Т.А., Воскобойникова И.В., Быков В.А. Лекарственные средства из растений. М. 2009. 431 с.
  7. Бортникова В.В., Крепкова Л.В., Арзамасцев Е.В., Кузнецов Ю.Б., Боровкова М.В. Противовоспалительные свойства некоторых растительных антимикробных и противовирусных препаратов. Сб. науч. трудов, посвящ. 70-летию Всероссийского научно-исследовательского института лекарственных и ароматических растений «Химия, Технология, Медицина». М. 2000. С. 369-375.

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies