Clinical prospects for using the Ki67 proliferation index in lymphogenic metastases in breast carcinoma


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Abstract

Вackground. The number of lymphogenic metastases in the axillary region is the most important predictor of parenchymal metastasis in breast cancer (BC). The proliferation index Ki67 (IP) in lymphogenic metastasis cells as a predictor of metastasis to parenchymal organs has not been studied enough to date. Patients and methods. Comparative analysis of IP in primary tumor cells and lymphogenic metastatic cells are done in 58 patients with luminal BC T1-4N1-3. Results. It was found that the discrepancy of IP (IPdis) in the cells of luminal BC and its lymphogenic metastases occurs in 82.8% of cases. It was found that lymphogenic metastases in the group of patients IP(-)dis higher than in patients IP(+)dis. However, the difference was not statistically significant. Much more detected significant IPdis. In 5 cases, a higher IP in lymphogenic metastatic cells may be the cause of diagnosis of aggressive luminal B molecular subtype of BC, followed by prediction of a higher risk of parenchymal metastasis. Conclusions. The results of comparative analysis of IP in primary tumor cells and lymphogenic metastatic cells in patients with luminal BC N1-3 in the long term can be used as a predictor of high metastatic potential and as a consequence of a short period of relapse-free survival.

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About the authors

A. S Balkanov

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Email: andreybalkanov@yandex.ru
Dr.Sc. (Med.), Head Department of Radiotherapy in the Section «Science»

L. E Gaganov

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Email: 6844325@mail.ru
Dr.Sc. (Med.), Leading Research Scientist, Department of Morphological Diagnostics, Oncology Department

I. D Rozanov

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Research Scientist, Department of Radiotherapy

E. I Shirikov

M.F. Vladimirsky Moscow Regional Clinical Research Institute

Research Scientist, Department of Radiotherapy

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