Analysis of level of leptin circulating in blood in the yakut population


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Abstract

Relevance. Adipose tissue is considered an endocrine organ that produces several hormonally active substances, including the hormone leptin. This hormone plays a key role in regulating energy homeostasis and thermoregulation and may be involved in microevolutionary mechanisms of human adaptation to cold climates. The purpose of this work is to analyze the levels of leptin in the blood of young Yakut people living in the Republic of Sakha (Yakutia). Material and methods. The sample included Yakuts 18-30 years old with a total population of 281 people (186 women and 95 men). For each participant, the body mass index (BMI) was calculated, and the level of leptin in the blood serum was determined. Results. The average leptin level in women was 18.95±0.9 ng/ml, in men 6.57±0.88 ng/ml. In the Yakut population, previously known leptin sexual dimorphism (p<0.001) was confirmed, where women have higher levels of leptin in contrast to men. The previously known dependence of blood leptin level on BMI was also confirmed in both women (r=0.4588; p=0.0000) and men (r=0.4385; p=0.00001). Conclusions. The results complement the available data on leptin levels and their relationship to gender and BMI in various human populations.

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About the authors

A. A Nikanorova

North-Eastern Federal University named M.K. Ammosov; Yakut Scientific Center of Complex Medical Problems

Email: nikanorova.alena@mail.ru
Post-graduate Student, Institute of Natural Science; Junior Research Scientist Yakutsk

N. A Barashkov

Yakut Scientific Center of Complex Medical Problems

Ph.D. (Biol.), Head of Laboratory Yakutsk

S. S Nakhodkin

North-Eastern Federal University named M.K. Ammosov

Engineer-researcher, Laboratory of Molecular Biology, Institute of Natural Sciences Yakutsk

V. G Pshennikova

Yakut Scientific Center of Complex Medical Problems

Ph.D. (Biol.), Head of Laboratory Yakutsk

A. V Solovyev

North-Eastern Federal University named M.K. Ammosov

Ph.D. (Biol.), Junior Research Scientist, Laboratory of Molecular Biology, Institute of Natural Sciences Yakutsk

G. P Romanov

North-Eastern Federal University named M.K. Ammosov

Engineer, Laboratory of Molecular Biology, Institute of Natural Sciences Yakutsk

S. S Kuzmina

North-Eastern Federal University named M.K. Ammosov

Ph.D. (Biol.), Associate Professor, Department of Biology, Institute of Natural Sciences Yakutsk

N. N Sazonov

North-Eastern Federal University named M.K. Ammosov

Dr.Sc. (Biol.), Professor, Department of Biology, Institute of Natural Sciences Yakutsk

S. A Fedorova

North-Eastern Federal University named M.K. Ammosov

Dr.Sc. (Biol.), Head of the Laboratory of Molecular Biology, Institute of Natural Sciences Yakutsk

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