Influence of the Rhaponticum uniflorum dry extract on the behavior of white rats in positive supported tests
- Authors: Razuvaeva Y.G1, Markova K.V2, Toropova A.A1, Olennikov D.N1
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Affiliations:
- Institute of General and Experimental Biology SB RAS
- Banzarov Buryat State University
- Issue: Vol 23, No 11 (2020)
- Pages: 28-33
- Section: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/112796
- DOI: https://doi.org/10.29296/25877313-2020-11-05
- ID: 112796
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Abstract
The purpose: of the study was to evaluate the Rhaponticum uniflorum L. DC. dry extract on the white rats behavior in positive supported tests. Material and methods: The studies were carried out on white Wistar rats. The R. uniflorum dry extract in the doses 50,100 and 200 mg/kg was administered {per os) to animals experimental groups. The amount of food ingested by the animals was measured in the hyponeophagia test. The food-procuring conditioned reflex was formed in a T-shaped labyrinth. Results. It was found that 63-88% of the animals ate food under unfamiliar conditions in the experimental groups, while in the control group only 38%. The food-procuring conditioned reflex was formed in 29 and 38% of animals treated with R. uniflorum at doses of 100 and 200 mg/kg, whereas in the control group, no animal reached the learning criterion. Against the background of the introduction of the R. uniflorum at a dose of 50 mg/kg, food-procuring conditioned reflex developed in 71% of the animals of the first experimental group. Conclusions. The R. uniflorum dry extract has an anxiolytic-like effect, promoting the adaptation of animals to unfamiliar conditions and increasing the amount of food in the hyponeophagia test, as well as faster development of the food-procuring conditioned reflexe in the T-shaped labyrinth.
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About the authors
Ya. G Razuvaeva
Institute of General and Experimental Biology SB RAS
Email: tatur75@mail.ru
Dr.Sc. (Biol.), Senior Research Scientist Ulan-Ude
K. V Markova
Banzarov Buryat State UniversityPost-graduate Student Ulan-Ude
A. A Toropova
Institute of General and Experimental Biology SB RASPh.D. (Biol.), Research Scientist Ulan-Ude
D. N Olennikov
Institute of General and Experimental Biology SB RASDr.Sc. (Pharm.), Senior Research Scientist Ulan-Ude
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