Growth factor of vessel endothelium in new coronaviral disease - 2019 (COVID-19) complicated with pneumoni


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Abstract

Theaimofthestudyistostudythevascularendothelialgrowthfactorinthenewcoronavirus disease -2019 (COVID-19). Material and methods.The object of the study is patients (36 men and 28 women, mean age 48.9 ± 15.3 years) with laboratory and clinical and epidemiologically confirmed diagnosis of COVID-19, complicated by pneumonia. The indicators of peripheral and biochemical blood were analyzed. Serum levels of vascular endothelial growth factor (VEGF) concentration were assessed by quantitative enzyme-linked immunosorbent assay. The patients were divided into 2 groups depending on gender (men, n = 36 (56.25%); women, n = 28 (43.75%) and the degree of blood oxygen saturation (group A, n = 26 (40.62%) Sa02 level below 90%; group B, n = 38 (59.38%) Sa02 level above 90%). Results. In the subgroup of men with COVID-19 complicated by pneumonia, significantly low levels of hemoglobin (Hb) oxygen saturation, lymphocyte counts, as well as high levels of leukocytes and blood creatinine were detected.The content of Hb and the average concentration of Hb in erythrocytes (MHC) were significantly lower among women with COVID-19 complicated by pneumonia. In a subgroup of men, there was a significant increase in VEGF concentration. A close relationship was recorded between concentration of VEGFandSat02(r=-0.341,p = 0.019),averageHbcontentinerythrocyte(MCH)(r=-0.201,p = 0.045),relativenumberoflym-phocytes (r = -0.362, p = 0.018), distribution width erythrocytes (r = 0.381, p = 0.010), the number of platelets (r = 0.503, p = 0.007), erythrocyte sedimentation rate(ESR) (r= 0.555, p = 0.001), as well as with the concentration of C-reactive protein (CRP) (r = 0.394, p = 0.005). Conclusion. The VEGF concentration correlates with the indices of Hb oxygen saturation, the number of platelets, the relative number of lymphocytes, the width of distribution of erythrocytes, ESR, MCH, as well asthe level of CRP in the blood. The predictor ofthe severity of COVID-19 in men was the level of oxygen saturation, the number of leukocytes, the relative number of lymphocytes and blood creatinine, and in females - additionally also the level of Hb and the MCHS indicator.

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About the authors

I. T Murkamilov

Kyrgyz State Medical Academy named after I. K. Akhunbaev; Kyrgyz-Russian Slavic University

Email: murkamilov.i@mail.ru
Ph.D. (Med.), Acting Associate Professor of the Department of faculty therapy; Senior Lecturer, Nephrologist, Chairman of the board of Chronic Kidney Disease Specialists Society of Kyrgyzstan

I. S Sabirov

Kyrgyz-Russian Slavic University

Email: sabirov_is@mail.ru
Dr.Sc. (Med.), Professor, Head of the Department ofTherapy № 2, board member of Chronic Kidney Disease Specialists Society of Kyrgyzstan

V. V Fomin

Skifosovsky Institute; I. M.Sechenov First Moscow State Medical University (Sechenov University) of the Ministry of Healthcare ofRussia

Email: fomin@mma.ru
Dr.Sc. (Med.), Professor, Corresponding Member of RAS, Head of the Department of Faculty Therapy № 1; Vice-rector in Clinical Workand continuous Professional Education

I. O Kudaibergenova

Kyrgyz State Medical Academy named after I.K. Akhunbaev

Email: k_i_o2403@mail.ru
Dr.Sc. (Med.), Professor,Rector

Zh. A Murkamilova

Kyrgyz-Russian Slavic University

Email: murkamilovazh.t@mail.ru
Post-graduate Student, the Department ofTherapy №2

F. A Yusupov

Osh State University

Email: furcat_y@mail.ru
Dr.Sc. (Med.), Professor, Head of the Department of Neurology, Neurosurgery and Psychiatry, Medicinal Faculty, Board Member of Chronic Kidney Disease Specialists Society of Kyrgyzstan; Chief NeurologistofSouthern Region of Kyrgyzstan

References

  1. Глыбочко П.В., Фомин В.В., Авдеев С.Н. и др. Клиническая характеристика 1007 больных тяжелой SARS-CoV-2 пневмонией, нуждавшихся в респираторной поддержке. Клин. Фармакол. тер. 2020; 29(2): 21-29. https://doi.org/10.32756/0869-5490-2020-2-21-29
  2. White D., Mac Donald S., Edwards Т., et al. Evaluation of COVID-19 coagulopathy; laboratory characterization using thrombin generation and nonconventional haemostasis assays.Intemational journal of laboratory hematology. 2021; 43(1): 123-130. https://doi.org/10.1111/ijlh.13329
  3. Qi X., Liu Y., Wang J., et al. Clinical course and risk factors for mortality of COVID-19 patients with pre-existing cirrhosis: a multicentre cohort study. Gut. 2021; 70(2): 433-436. http://dx.doi.org/10.1136/gutjnl-2020-321666
  4. Ильченко Л.Ю., Никитин И.Г., Федоров И.Г. COVID-19 ипоражениепечени. Архивъ внутренней медицины. 2020; 10(3): 188-197. https://doi.org/10.20514/2226-6704-2020-10-3-188-197
  5. Сабиров И.С., Муркамилов И.Т., Фомин В.В. Гепатобилиарная система и новая коронавирусная инфекция (СО-VID-19). The Scientific Heritage. 2020; 49-2(49): 49-58.
  6. Xiaoqi W., Xin B., Xu Z., et al. Network Representation Learning-based Drug Mechanism Discovery and Antiinflammatory Response against COVID-19.2020. https://doi.org/10.26434/chemrxiv.12531314.v2
  7. Villegas G., Lange-Spemndio B., Tufro A. Autocrine and paracrine functions of vascular endothelial growth factor (VEGF) in renal tubular epithelial cells. Kidney international. 2005; 67(2): 449457. https://doi.org/10.1111/j.l523-1755.2005.67101.x
  8. Мнихович M.B., Гершзон Д., Брикман М. и др. Морфогенетические механизмы клеточных взаимодействий в процессе ангиогенеза. Журнал анатомии и гистопатологии. 2012; 1(3): 53-65.
  9. Todderud G., Carpenter G. Epidermal growth factor: the receptor and its function. Bio Factors. 1999; 2(1): 11-15.
  10. Захарова H., Воскресенская О., Тарасова Ю. Ангиогенез и фактор роста эндотелия сосудов при цереброваскулярной патологии. Врач. 2014; 10: 12-14.
  11. Ghazizadeh Н., Rezaei М., Avan A., et al. Association between serum cell adhesion molecules with hs-CRP, uric acid and VEGF genetic polymorphisms in subjects with metabolic syndrome. Molecular biology reports. 2020; 47(2): 867-875. https://doi.org/10.1007/sll033-019-05081-2
  12. Муркамилов И.Т., Айтбаев К.А., Фомин В.В. и др. Исследование эндотелиального фактора роста сосудов, маркеров воспаления и жесткости сосудов при хронической болезни почек. Клиническая нефрология. 2020; 2: 43-51. https://dx.doi.Org/10.18565/nephrology.2020.2.43-51
  13. Smets P., Devauchelle-Pensec V., Rouzaire P.O., et al. Vascular endothelial growth factor levels and rheumatic diseases of the elderly. Arthritis Res. Ther. 2016; 18(1): 283. Published 2016 Dec 1. https://dx.doi.org/10.1186/sl3075-016-1184-x
  14. Никифоров B.B., Суранова Т.Г., Чернобровкина Т.Я. и др. Новая коронавирусная инфекция (COVID-19): клиникоэпидемиологические аспекты. Архивъ внутренней медицины. 2020; 10(2): 87-93. https://doi.org/10.20514/2226-6704-2020-10-2-87-93
  15. Камкин Е.Г. Профилактика, диагностика и лечение новой коронавирусной инфекции (COVID-19). Временные методические рекомендации. М.: Министерство Здравоохранения Российской Федерации. 2020.
  16. Bradley В. Т., Maioli Н, Johnston R., et al. Histopathology and ultrastructural findings of fatal COVID-19 infections in Washington State: a case series. The Lancet. 2020; 396(10247): 320-332. https://doi.org/10.1016/S0140-6736(20)31305-2
  17. Borczuk A.C., Salvatore S.P., Seshan S.V., et al. COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City.Mod Pathol. 2020. https: //doi.org/10.1038/s41379-020-00661 -1
  18. Park М., Jung H.L., Shim Y.J., et al. Serum cytokine profiles in infants with infantile hemangiomas on oral propranolol treatment: VEGF and bFGF, potential biomarkers predicting clinical outcomes.Pediatric Research. 2020; 1-7. https: //doi.org/10.103 8/s413 90-020-0862-1
  19. Felmerer G., Stylianaki A., Hollmen М., et al. Increased levels of VEGF-C and macrophage infiltration in lipedema patients without changes in lymphatic vascular morphology. Scientific Reports. 2020; 10(1): 1-10. https://doi.org/-10.1038/s41598-020-67987-3
  20. Kong Y., Han J., Wu X., et al. VEGF-D: a novel biomarker for detection of COVID-19 progression.Critical Care. 2020; 24 (1): -4. https://doi.org/10.1186/sl3054-020-03079-y
  21. Yin XX., Zheng X.R., Peng W., et al. Vascular Endothelial Growth Factor (VEGF) as a Vital Target for Brain Inflammation during the COVID-19 Outbreak. ACS Chemical Neuroscience. 2020. https://doi.org/10.1021/acschemneuro.0c00294
  22. Dong G., Lin X.H., Liu H.H., et al. Intermittent hypoxia alleviates increased VEGF and pro-angiogenic potential in liver cancer cells. Oncology letters. 2019; 18(2): 1831-1839. https://doi.org/10.3892/ol.2019.10486
  23. Синопальников А.И. Американские (ATS/IDSA, 2019) и российские (PPO/MAKMAX, 2019) рекомендации по ведению внебольничной пневмонии у взрослых. Два взгляда на актуальную проблему. Consilium Medicum. 2020; 22 (3): 22-27. https://doi.Org/10.26442/20751753.2020.3.200084
  24. §ener A., Kurtoglu Qelik G., Ozhasenekler A., et al. Evaluation of dynamic thiol/disulfide homeostasis in adult patients with community-acquired pneumonia. Hong Kong Journal of Emergency Medicine. 2019; 26(6): 343-350. https://doi.org/10.1177/1024907918802956
  25. Price L.C., Me Cabe C., Garfield B., Wort S.J. Thrombosis and COVID-19 pneumonia: the clot thickens! 2020; 56: 2001608. https://doi.org/10.1183/13993003.01608-2020
  26. Муркамилов И. Т. Цитокиновый статус при новой коронавирусной болезни (COVID-19). Вестник КРСУ. 2020; 20(9): 55-65.

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