Assessment of the hepatotoxic potential of organot in compounds containing 2,6-di-tert-butylphenol fragme


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Abstract

The article is devoted to the in vivo study of the effect of organotin compounds containing 2,6-di-tert-butylphenol fragment on liver mor- pho-functional state. The aim of this study was to evaluate the biochemical and histological changes in the liver with a single intragastric administration of bis (3,5-di-tert-butyl-4-hydroxyphenylthiolate) dimethyltin (Me3) and (3,5-di-tert-butyl-4-hydroxyphenylthiolate) triphenyltin (Me5) to Wistar rats (female) at the maximum tolerated dose (MTD) of 2000 mg/kg and 750 mg/kg, respectively. It was found that the introduction of Me3 and Me5 do not cause significant structural changes in liver, and the disorders are of a functional nature. The results of this work allow us to conclude that the hepatotoxicity of organotin compounds containing 2,6-di-tert-butylphenol is low, which opens up broad prospects for studying these compounds as candidates for antitumor drugs

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About the authors

M. A Dodokhova

Rostov State Medical University

Email: dodohova@mail.ru
Ph.D. (Med.), Associate Professor, Department of Biomedicine and Neuroscience, and General and Clinical Biochemistry No. 2

A. V Safronenko

Rostov State Medical University

Email: andrejsaf@mail.ru
Dr.Sc. (Med.), Professor, Department of Pharmacology and Clinical Pharmacology

I. M Kotieva

Rostov State Medical University

Email: kukulik70@mail.ru
Dr.Sc. (Med.), Professor, Department of Pathological Physiology

E. R Milaeva

Lomonosov Moscow State University

Email: milaeva@med.chem.msu.ru
Dr.Sc. (Chem.), Professor, Department of Medicinal Chemistry and Fine Organic Synthesis

D. B Shpakovsky

Lomonosov Moscow State University

Email: dmshpak@mail.ru
Ph.D. (Chem.), Senior Researcher, Department of Medicinal Chemistry and Fine Organic Synthesis

Yu. M Makarenko

Pathologic and Anatomical Bureau of the Russian Academy of Sciences

Email: markovich1962@yandex.ru
Ph.D. (Med.)

V. G Trepel

Federal State Budgetary Institution "IMCEUAOSMP" of Roszdravnadzor

Email: vartantrepel.61@gmail.com
Ph.D. (Med.), Rostov-on-Don branch

M. S Alkhuseyn-Kulyaginova

Rostov State Medical University

Email: rita.kuljaginva@rambler.ru
Senior Laboratory Assistant, Department of Chemistry

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