Criteria for evaluating the qualitative and quantitative characteristics of microcapsules


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Abstract

The review presents material on the peculiarities of methods for assessing the quality of microcapsules of drug substances and the potential application of formal techniques and additional tests proposed for active pharmaceutical substances enclosed in microcapsules. We analyzed domestic and foreign sources of open access literature; the following digital databases were used: PubMed, Elibrary, CyberLenincka and the Google Scholar search engine. The effective tests proposed for microencapsulated substances and the need for additional tests for microcapsules depending on their composition and purpose were identified. Opportunities of microcapsules standardization as a dosage form for effective evaluation and understanding of qualitative and quantitative characteristics while considering microparticles as a pharmaceutical substance and a dosage form intended for use were described.

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About the authors

O. A Semkina

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Email: semkinaolga@gmail.com
Ph.D. (Pharm.)

O. M Beloshapkina

Lomonosov Moscow State University; All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Post-graduate Student

M. A Dzhavakhyan

All-Russian Scientific Research Institute of Medicinal and Aromatic Plants

Dr.Sc. (Pharm.)

References

  1. Garg A., Chhipa K., Kumar L. Microencapsulation Techniques in Pharmaceutical Formulation. European Journal of Pharmaceutical and Medical Research. 2018; 5(3): 199-206.
  2. Чуешов В.И., Гладух Е.В., Сайко И.В. Технология лекарств промышленного производства. В 2-х частях. Винница: Новая книга. 2014. 696 с.
  3. Carvalho I.T., Estevinho B.N., Santos L. Application of microencapsulated essential oils in cosmetic and personal healthcare products - a review. International Journal of Cosmetic Science. 2016; 38(2): 109-119.
  4. Farheen T., Shaikh A., Shahi S. A Review on a Process: Microencapsulation. Int. J. Pharma Res. Health Sci. 2017; 5(5): 1823-1830.
  5. Surini S., Nursatyani K., Ramadon D. Gel formulation containing microcapsules of grape seed oil (Vitis vinifera L.) for skin moisturizer. Journal of Young Pharmacists. 2018; 10(1): 41-47.
  6. Neubauer M.P., Poehlmann M., Fery A. Microcapsule mechanics: From stability to function. Advances in Colloid and Interface Science. 2014; 207: 65-80.
  7. Lengyel M., Kallai-Szabo N., Antal V. et al. Microparticles, microspheres, and microcapsules for advanced drug delivery. Scientia Pharmaceutica. 2019; 87(20): 1-31.
  8. Prakash K., Raju P.N., Shanta K.K. et al. Preparation and characterization of lamivudine microcapsules using various cellulose polymers. Tropical Journal of Pharmaceutical Research. 2007; 6(4): 841-847.
  9. Antonio-Gomez M.V., Salinas-Moreno Y., Hernandez-Rosas F. et al. Optimised extraction, microencapsulation, and stability of anthocyanins from Ardisia compressa K. fruit. Pol. J Food Nutr Sci. 2021; 71(3): 299-310.
  10. Степанова Э.Ф., Ким М.Е., Мурзагулова К.Б., Евсеева С.Б. Микрокапсулы: перспективы использования в современной фармацевтической практике. Соврем. пробл. науки и образ. 2014; 5: 1-8.
  11. Pudziuvelyte L., Marksa M., Jakstas V., et al. Microencapsulation of Elsholtzia ciliata herb ethanolic extract by spray-drying: impact of resistant-maltodextrin complemented with sodium caseinate, skim milk, and beta-cyclodextrin on the quality of spray-dried powders. Molecules. 2019; 24(1461): 1-22.
  12. Yan X., Zhao W., Qian X. Effect of water-based emulsion core microcapsules on aging resistance and self-repairing properties of water-based coatings on linden. Applied Sciences. 2021; 11(10): 1-15.
  13. Полковникова Ю.А., Сливкин А.И. Способ количественного определения фенибута в микрокаспулах методом капиллярного электрофореза. Патент России № 2642275.2006. Бюл. № 3.
  14. Manjanna K.M., Shivakumar B., Pramod Kumar T.M. Microencapsulation: An acclaimed Novel Drug-Delivery System for NSAIDs in arthritis. Critical Reviews in Therapeutic Drug Carrier Systems. 2010; 27(6): 501-532.
  15. Мусабаева Б.Х., Мурзагулова К.Б., Ким М.Е. и др. Получение микрокапсул противотуберкулезных препаратов на основе биополимеров и полиэлектролитов. Фармация и фармакология. 2017; 5(2): 164-176.
  16. Devi M., Dutta S., Hinai A.H., Feroz S. Studies on encapsulation of Rifampicin and its release from chitosan-dextran sulfate capsules. Korean Journal of Chemical Engineering. 2015; 32(1): 118-124.
  17. Грехнёва Е.В., Власова В.В. Особенности микрокапсулирования окситетрациклина и цефтриаксона в двойные оболочки. Auditorium. 2017; 2: 1-5.

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