Peptide therapy in clinical pharmacology: current state and promising directions of development


Cite item

Full Text

Open Access Open Access
Restricted Access Access granted
Restricted Access Subscription or Fee Access

Abstract

Insulin therapy initiated the use of peptides in incurable diseases at the beginning of the 20th century. Over time, peptide science has evolved in sync with other scientific discoveries and has finally expanded its view beyond the traditional focus on human endogenous peptides to reveal a broader range of peptide agents identified from other resources or through medicinal chemistry. The article is a literary review of publications in the Russian scientific electronic library eLIBRARY and in the PubMed library of the USA National Center for Biotechnology Information (NCBI). As a result of the analysis, the formulation of peptide therapy, the current state of the development of peptide therapy, the strengths and weaknesses of peptides as drugs, and emerging new opportunities in the design and development of peptide drugs are outlined.

Full Text

Restricted Access

About the authors

N. T Arkhincheeva

Buryat State University

Author for correspondence.
Email: norjima01@mail.ru
Post-graduate Student, Department of Pharmacology and Traditional Medicine, Medical Institute Ulan-Ude, Russia

I. M Balkhaev

Buryat State University

Email: ill.balkhaev@mail.ru
Dr.Sc. (Med.), Associate Professor, Medical Institute Ulan-Ude, Russia

References

  1. Lau J.L., Dunn M.K. Therapeutic peptides: Historical perspectives, current development trends, and future directions. Bioorganic & Medicinal Chemistry. 2018; 26(10): 27002701.
  2. Davenport A.P., Scully C.C.G., de Graaf. C., Brown A.J. H., Maguire J.J. Advances in therapeutic peptides targeting G protein-coupled receptors. Nature Reviews Drug Discovery. 2020; 19: 389-391.
  3. Zhang Y., Zhang H., Ghosh D., Williams IIIR.O. Just How Prevalent are Peptide Therapeutic Products? A Critical Review.International Journal of Pharmaceutics. 2020; 587: 119491.
  4. Sato A.K., Viswanathan M., Kent R.B. et al. Therapeutic peptides: technological advances driving peptides into development. Current Opinion in Biotechnology. 2006; 17(6): 638.
  5. Craik D. J., Fairlie D. P., Liras S., Price D. The Future of Peptide-based Drugs. Chemical Biology & Drug Design. 2012; 81(1): 137-139.
  6. Ghosh D., Peng X., Leal J., Mohanty R. Peptides as drug delivery vehicles across biological barriers. Journal of pharmaceutical investigation. 2018; 48: 89-111.
  7. Gongora-Benltez M., Tulla-Puche J., Albericio F. Multifaceted Roles of Disulfide Bonds. Peptides as Therapeutics. Chemical Reviews. 2014; 114: 901-926.
  8. Padhi A., Sengupta M., Sengupta S., Roehm K. H., Sonawane A. Antimicrobial peptides and proteins in mycobacterial therapy: Current status and future prospects. Tuberculosis. 2014; 94(4): 363-373.
  9. Kaspar A.A., Reichert J.M. Future directions for peptide therapeutics development. Drug Discovery Today. 2013; 18(17): 807-817.
  10. Aldous A. R., Dong J. Z. Personalized neoantigen vaccines: A new approach to cancer immunotherapy. Bioorganic & Medicinal Chemistry. 2018; 26(10): 2842-2849.
  11. Diao L., Meibohm B. Pharmacokinetics and Pharmacokinetic-Pharmacodynamic Correlations of Therapeutic Peptides. Clinical Pharmacokinetics. 2013; 52(10): 856.
  12. Drucker D.J. Advances in oral peptide therapeutics. Nat Rev Drug Discov. 2020; 19: 278.
  13. Fosgerau K., Hoffmann T. Peptide therapeutics: current status and future directions. Drug Discovery Today. 2015; 20(1): 122-128.
  14. Habault J., Poyet J-L. Recent Advances in Cell Penetrating Peptide-Based Anticancer Therapies. Molecules. 2019; 24(5): 927.
  15. Хавинсон В.Х., Соловьев А.Ю., Тарновская С.И., Линькова H.С. Механизм биологической активности коротких пептидов: проникновение в клетку и эпигенетическая регуляция экспрессии генов. Успехи современной биологии. 2013; 133(3): 310-316
  16. Henninot A., Collins J.C., Nuss J.M. The Current State of Peptide Drug Discovery: Back to the Future? Journal of Medicinal Chemistry. 2017; 61(4): 1382-1414.
  17. Бабина С.А., Желтышева А.Ю., Шуклин Г.О. и др. Лекарственные средства на основе пептидов: применение, технологии получения. Международный студенческий научный вестник. 2019; 3-21
  18. Петров В.И., Шишиморов И.Н., Магницкая О.В., Толкачев Б.Е. Персонализированная медицина: эволюция методологии и проблемы практического внедрения. Вестник Волгоградского государственного медицинского университета. 2016; 57: 1-11
  19. Magnickaya O.V., Tolkachev B.E. Personalizirovannaya medicina: evolyuciya metodologii i problemy prakticheskogo vnedreniya. Vestnik Volgogradskogo gosudarstvennogo medicinskogo universiteta. 2016; 57: 1-11

Supplementary files

Supplementary Files
Action
1. JATS XML

This website uses cookies

You consent to our cookies if you continue to use our website.

About Cookies