Chemometric approach to investigation of the role of adipose tissue as a target for toxic metal effects


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Abstract

The objective of the present study was to assess toxic metal content in human adipose tissue and evaluate patterns of toxic and essential trace element accumulation in adipose tissue compared to liver.

Material and methods. The samples of right-sided pararenal adipose tissue and right lobe of the liver were obtained from autopsy of 28 patients aged from 33 to 63 years old who died from complications of cardiovascular diseases.

Results. Assessment of toxic and essential element levels was performed using inductively-coupled plasma mass spectrometry. The obtained data demonstrate comparable levels of toxic metals in adipose tissue and liver. Specifically, no significant group difference in aluminium and arsenic content was observed between liver and adipose tissue. Lead and tin content in adipose tissue was 23% and 46% lower than that in liver, respectively. At the same time, the levels of cadmium and mercury in liver exceeded the respective values in adipose tissue by a factor of 2.6 and 4.5. In view of manyfold differences in total protein levels in adipose tissue and liver, toxic metal accumulation in adipocyte cytoplasm far exceeds that in hepatocytes.

Conclusion. Therefore, the obtained data demonstrate that adipose tissue may be considered as a target for toxic metal effects, thus underlying the epidemiological association between toxic metal exposure and obesity prevalence.

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About the authors

A. V. Skalny

Sechenov University; RUDN University

Author for correspondence.
Email: skalny3@microelements.ru

Dr.Sc. (Med.), Professor, Director of the Center for Bioelementology and Human Ecology; Head of Department of Medical Elementology

Russian Federation, Moscow; Moscow

V. N. Nikolenko

Sechenov University; Moscow State University

Email: nikolenko_v_n@staff.sechenov.ru

Dr.Sc. (Med.), Professor, Head of Department of Human Anatomy; Head of Department General and Topographic Anatomy

Russian Federation, Moscow; Moscow

T. Kh. Fatkhudinov

RUDN University; Research Institute of Human Morphology

Email: tfat@yandex.ru

Dr.Sc. (Med.), Head of Department of Histology, Cytology and Embryolog, Institute of Medicine; Director for Scientific Development

Russian Federation, Moscow; Moscow

Jung-Su Chang

Taipei Medical University

Email: susanchang@tmu.edu.tw

PhD, Professor

Taiwan, Province of China, Taipei

G. D. Morozova

Sechenov University; Golikov Research Center of Toxicology

Email: morozova0826@gmail.com

Laboratory Assistant, Laboratory of Molecular Nutrition; Junior Research Scientist

Russian Federation, Moscow; Saint-Petersburg

G. V. Zolotenkova

Sechenov University; State Budgetary Healthcare Institution of Moscow Bureau of SME

Email: zolotenkova_g_v@staff.sechenov.ru

Dr.Sc. (Med.), Professor, Department of Forensic Medicine; Doctor – Forensic Medical Expert

Russian Federation, Moscow; Moscow

Shih-Yi Huang

Taipei Medical University

Email: sihuang@tmu.edu.tw

PhD, Professor, Graduate Institute of Metabolism and Obesity Sciences)

Taiwan, Province of China, Taipei

A. A. Tinkov

Sechenov University; RUDN University

Email: tinkov.a.a@gmail.com

Dr.Sc. (Med.), Leading Research Scientist, Laboratory of Molecular Nutrition; Associate Professor, Department of Medical Elementology

Russian Federation, Moscow; Moscow

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