Chemometric approach to investigation of the role of adipose tissue as a target for toxic metal effects
- 作者: Skalny A.V.1,2, Nikolenko V.N.1,3, Fatkhudinov T.K.2,4, Chang J.5, Morozova G.D.1,6, Zolotenkova G.V.1,7, Huang S.5, Tinkov A.A.1,2
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隶属关系:
- Sechenov University
- RUDN University
- Moscow State University
- Research Institute of Human Morphology
- Taipei Medical University
- Golikov Research Center of Toxicology
- State Budgetary Healthcare Institution of Moscow Bureau of SME
- 期: 卷 25, 编号 12 (2022)
- 页面: 3-9
- 栏目: Articles
- URL: https://journals.eco-vector.com/1560-9596/article/view/321642
- DOI: https://doi.org/10.29296/25877313-2022-12-01
- ID: 321642
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详细
The objective of the present study was to assess toxic metal content in human adipose tissue and evaluate patterns of toxic and essential trace element accumulation in adipose tissue compared to liver.
Material and methods. The samples of right-sided pararenal adipose tissue and right lobe of the liver were obtained from autopsy of 28 patients aged from 33 to 63 years old who died from complications of cardiovascular diseases.
Results. Assessment of toxic and essential element levels was performed using inductively-coupled plasma mass spectrometry. The obtained data demonstrate comparable levels of toxic metals in adipose tissue and liver. Specifically, no significant group difference in aluminium and arsenic content was observed between liver and adipose tissue. Lead and tin content in adipose tissue was 23% and 46% lower than that in liver, respectively. At the same time, the levels of cadmium and mercury in liver exceeded the respective values in adipose tissue by a factor of 2.6 and 4.5. In view of manyfold differences in total protein levels in adipose tissue and liver, toxic metal accumulation in adipocyte cytoplasm far exceeds that in hepatocytes.
Conclusion. Therefore, the obtained data demonstrate that adipose tissue may be considered as a target for toxic metal effects, thus underlying the epidemiological association between toxic metal exposure and obesity prevalence.
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作者简介
A. Skalny
Sechenov University; RUDN University
编辑信件的主要联系方式.
Email: skalny3@microelements.ru
Dr.Sc. (Med.), Professor, Director of the Center for Bioelementology and Human Ecology; Head of Department of Medical Elementology
俄罗斯联邦, Moscow; MoscowV. Nikolenko
Sechenov University; Moscow State University
Email: nikolenko_v_n@staff.sechenov.ru
Dr.Sc. (Med.), Professor, Head of Department of Human Anatomy; Head of Department General and Topographic Anatomy
俄罗斯联邦, Moscow; MoscowT. Fatkhudinov
RUDN University; Research Institute of Human Morphology
Email: tfat@yandex.ru
Dr.Sc. (Med.), Head of Department of Histology, Cytology and Embryolog, Institute of Medicine; Director for Scientific Development
俄罗斯联邦, Moscow; MoscowJung-Su Chang
Taipei Medical University
Email: susanchang@tmu.edu.tw
PhD, Professor
台湾, TaipeiG. Morozova
Sechenov University; Golikov Research Center of Toxicology
Email: morozova0826@gmail.com
Laboratory Assistant, Laboratory of Molecular Nutrition; Junior Research Scientist
俄罗斯联邦, Moscow; Saint-PetersburgG. Zolotenkova
Sechenov University; State Budgetary Healthcare Institution of Moscow Bureau of SME
Email: zolotenkova_g_v@staff.sechenov.ru
Dr.Sc. (Med.), Professor, Department of Forensic Medicine; Doctor – Forensic Medical Expert
俄罗斯联邦, Moscow; MoscowShih-Yi Huang
Taipei Medical University
Email: sihuang@tmu.edu.tw
PhD, Professor, Graduate Institute of Metabolism and Obesity Sciences)
台湾, TaipeiA. Tinkov
Sechenov University; RUDN University
Email: tinkov.a.a@gmail.com
Dr.Sc. (Med.), Leading Research Scientist, Laboratory of Molecular Nutrition; Associate Professor, Department of Medical Elementology
俄罗斯联邦, Moscow; Moscow参考
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