Characteristics of the amino acid profile of blood plasma in psoriasis
- Authors: Kupriyanov S.V.1, Shatrova Y.M.1, Sysakov D.A.1, Fedorova K.S.1, Myakotina D.E.1, Kholina A.N.2, Sinitsky A.I.1
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Affiliations:
- South Ural State Medical University
- Chelyabinsk Regional Blood Transfusion Station
- Issue: Vol 26, No 5 (2023)
- Pages: 10-17
- Section: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/430409
- DOI: https://doi.org/10.29296/25877313-2023-05-02
- ID: 430409
Cite item
Abstract
Introduction. Psoriasis is an autoimmune disease that affects the skin, has a number of systemic manifestations and is associated with the development of a number of somatic pathologies. It is known that one of the systemic features of psoriasis is changes in the blood plasma amino acid pool, but the pathogenetic significance of this fact has not yet been determined.
The purpose of this work was to study the amino acid profile of blood plasma in psoriasis and its relationship with biochemical markers of lipid and purine metabolism.
Materials and methods. The study group included 45 patients with psoriasis vulgaris. The comparison group included 46 donors of the Chelyabinsk Regional Blood Transfusion Station. The concentrations of 20 proteinogenic amino acids, as well as ornithine and citrulline, were determined.
Results. Recorded changes demonstrating the rearrangement of relationships between the concentrations of circulating amino acids in psoriasis; correlations of amino acid levels with a number of clinical diagnostic biochemical markers in the group of patients with psoriasis were determined. A significant increase in the levels of cysteine, phenylalanine and leucine was found in psoriasis compared with the corresponding indicators of the comparison group. Cysteine concentrations positively correlated with uric acid levels. Elevated levels of cysteine and leucine have been associated with disorders of purine and lipid metabolism.
Conclusions. The data obtained indicate changes in the amino acid profile in psoriasis, some of which may be associated with the development of comorbid metabolic pathologies.
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About the authors
S. V. Kupriyanov
South Ural State Medical University
Author for correspondence.
Email: pfft@mail.ru
Post-graduate Student, Department of Biochemistry named after R.I. Lifshitz
Russian Federation, ChelyabinskYu. M. Shatrova
South Ural State Medical University
Email: pfft@mail.ru
Ph.D. (Biol.), Researcher, Research Institute of Immunology
Russian Federation, ChelyabinskD. A. Sysakov
South Ural State Medical University
Email: pfft@mail.ru
Ph.D. (Med.), Assistant of the Department of Dermatovenereology
Russian Federation, ChelyabinskK. S. Fedorova
South Ural State Medical University
Email: pfft@mail.ru
Senior Laboratory Assistant, Research Institute of Immunology
Russian Federation, ChelyabinskD. E. Myakotina
South Ural State Medical University
Email: pfft@mail.ru
Senior Laboratory Assistant, Research Institute of Immunology
Russian Federation, ChelyabinskA. N. Kholina
Chelyabinsk Regional Blood Transfusion Station
Email: pfft@mail.ru
transfusiologist, Head of the Department of Blood Procurement and its Components
Russian Federation, ChelyabinskA. I. Sinitsky
South Ural State Medical University
Email: pfft@mail.ru
Dr.Sc. (Med.), Associate Professor, Head of the Department of Biochemistry named after R.I. Lifshitz
Russian Federation, ChelyabinskReferences
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