Characteristics of the amino acid profile of blood plasma in psoriasis
- 作者: Kupriyanov S.V.1, Shatrova Y.M.1, Sysakov D.A.1, Fedorova K.S.1, Myakotina D.E.1, Kholina A.N.2, Sinitsky A.I.1
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隶属关系:
- South Ural State Medical University
- Chelyabinsk Regional Blood Transfusion Station
- 期: 卷 26, 编号 5 (2023)
- 页面: 10-17
- 栏目: Medical chemistry
- URL: https://journals.eco-vector.com/1560-9596/article/view/430409
- DOI: https://doi.org/10.29296/25877313-2023-05-02
- ID: 430409
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详细
Introduction. Psoriasis is an autoimmune disease that affects the skin, has a number of systemic manifestations and is associated with the development of a number of somatic pathologies. It is known that one of the systemic features of psoriasis is changes in the blood plasma amino acid pool, but the pathogenetic significance of this fact has not yet been determined.
The purpose of this work was to study the amino acid profile of blood plasma in psoriasis and its relationship with biochemical markers of lipid and purine metabolism.
Materials and methods. The study group included 45 patients with psoriasis vulgaris. The comparison group included 46 donors of the Chelyabinsk Regional Blood Transfusion Station. The concentrations of 20 proteinogenic amino acids, as well as ornithine and citrulline, were determined.
Results. Recorded changes demonstrating the rearrangement of relationships between the concentrations of circulating amino acids in psoriasis; correlations of amino acid levels with a number of clinical diagnostic biochemical markers in the group of patients with psoriasis were determined. A significant increase in the levels of cysteine, phenylalanine and leucine was found in psoriasis compared with the corresponding indicators of the comparison group. Cysteine concentrations positively correlated with uric acid levels. Elevated levels of cysteine and leucine have been associated with disorders of purine and lipid metabolism.
Conclusions. The data obtained indicate changes in the amino acid profile in psoriasis, some of which may be associated with the development of comorbid metabolic pathologies.
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作者简介
S. Kupriyanov
South Ural State Medical University
编辑信件的主要联系方式.
Email: pfft@mail.ru
Post-graduate Student, Department of Biochemistry named after R.I. Lifshitz
俄罗斯联邦, ChelyabinskYu. Shatrova
South Ural State Medical University
Email: pfft@mail.ru
Ph.D. (Biol.), Researcher, Research Institute of Immunology
俄罗斯联邦, ChelyabinskD. Sysakov
South Ural State Medical University
Email: pfft@mail.ru
Ph.D. (Med.), Assistant of the Department of Dermatovenereology
俄罗斯联邦, ChelyabinskK. Fedorova
South Ural State Medical University
Email: pfft@mail.ru
Senior Laboratory Assistant, Research Institute of Immunology
俄罗斯联邦, ChelyabinskD. Myakotina
South Ural State Medical University
Email: pfft@mail.ru
Senior Laboratory Assistant, Research Institute of Immunology
俄罗斯联邦, ChelyabinskA. Kholina
Chelyabinsk Regional Blood Transfusion Station
Email: pfft@mail.ru
transfusiologist, Head of the Department of Blood Procurement and its Components
俄罗斯联邦, ChelyabinskA. Sinitsky
South Ural State Medical University
Email: pfft@mail.ru
Dr.Sc. (Med.), Associate Professor, Head of the Department of Biochemistry named after R.I. Lifshitz
俄罗斯联邦, Chelyabinsk参考
- Chapel H., Haeney M., Misbah S.A., Snowden N. Essentials of Clinical Immunology. Includes Wiley E-Text. 6th Edition. 2013.
- Yamanaka K., Yamamoto O., Honda T. Pathophysiology of psoriasis: a review. The Journal of Dermatology. 2021; 48(6): 722–731.
- Yamazaki F. Psoriasis: Comorbidities. The Journal of Dermatology. 2021; 48(6): 732–740.
- Yan D., Afifi L., Jeon C., Trivedi M., Chang H.W., Lee K., Liao W. The metabolomics of psoriatic disease. Psoriasis (Auckl). 2017; 7: 1–15. doi: 10.2147/PTT.S118348.
- Tarentini E., Odorici G., Righi V., et al. Integrated metabolomic analysis and cytokine profiling define clusters of immuno-metabolic correlation in new-onset psoriasis. Sci. Rep. 2021; 11: 10472; https://doi.org/10.1038/s41598-021-89925-7.
- Poinsot V., Ong-Meang V., Gavard P., Francois C. Recent advances in amino acid analysis using capillary electromigration methods. 20132015. Electrophoresis. 2016; 37(1): 142–161.
- Kandasamy P. Gyimesi G., Kanai Y., Hediger M.A. Amino acid transporters revisited: New views in health and disease. Trends in biochemical sci-ences. 2018; 43(10): 752–789.
- Yu L., Zhu Q., Li Yu., et al. Dietary Branched-Chain Amino Acids (BCAAs) and Risk of Dyslipidemia in a Chinese Population. Nutrients. 2022; 14(9): 1824.
- Knapp A., Grimm U., Postrach E. Phenylalanine-tyrosine metabolism in psoriasis vulgaris. Search on a genetic basic defect (author's transl). Dermatologische Monatschrift. 1980; 166(7): 470–477.
- Dutkiewicz E.P., Hsieh K.T., Wang Y.S. et al. Hydrogel micropatch and mass spectrometry–assisted screening for psoriasis-related skin metabo-lites. Clinical Chemistry. 2016; 62(8): 1120–1128.
- Aterido A., Julià A., Ferrándiz C., et al. Genome-wide pathway analysis identifies genetic pathways associated with psoriasis. Journal of Investigative Dermatology. 2016; 136(3): 593–602.
- Gannon N.P., Schnuck J.K., Vaughan R.A. BCAA metabolism and insulin sensitivity–dysregulated by metabolic status? Molecular nutrition & food research. 2018; 62(6): 1700756.
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