The levels of essential trace elements in blood serum and urine of women with osteoporosis

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Abstract

The objective of the study was to assess serum and urinary concentrations of essential trace elements in women with osteoporosis.

Material and methods. A total of 100 women aged 30-70 years old including 50 patients with osteoporosis (ICD-10: M81) and 50 healthy controls were examined. Assessment of serum and urinary trace element levels was performed using inductively-coupled plasma mass-spectrometry.

Results. The obtained data demonstrate that urinary cobalt and zinc levels in women with osteoporosis were 42% and 44% lower than those in the control women. Analysis of covariance demonstrated a significant impact of osteoporosis and body mass index (BMI) values on urinary Zn concentration. The influence of the presence of osteoporosis on urinary Co concentration was nearly significant. At the same time, serum Co concentration in osteoporotic women was 21% lower than in healthy controls, while no significant difference in serum Zn levels was observed. The presence of osteoporosis in the examined women was also considered a key factor affecting serum Co levels independently of age and BMI values.

Conclusion. Therefore, the results of the present study demonstrated the association between Zn and Co deficiency and the presence of osteoporosis in women. It is suggested that personalized correction of body burden of these trace elements may reduce the risk of osteoporosis due to osteogenic effect of zinc and cobalt. At the same time, intimate mechanisms of this association, as well as efficiency of supplementation strategies in management of osteoporosis requires further investigation.

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About the authors

T. V. Korobeinikova

I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia (RUDN University)

Author for correspondence.
Email: tatcvetk@yandex.ru

Ph.D. (Tech.), Head of Laboratory of Molecular Dietetics of the Center for Bielementology and Human Ecology, Associate Professor of the Department of Medical Elementology

Russian Federation, Moscow; Moscow

E. V. Rylina

I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia (RUDN University)

Email: tatcvetk@yandex.ru

Ph.D. (Pharm.), Leading Research Scientist, Laboratory of Molecular Nutrition, Center for Bielementology and Human Ecology, Associate Professor of the Department of Medical Elementology

Russian Federation, Moscow; Moscow

A. M. Mazaletskaya

I.M. Sechenov First Moscow State Medical University (Sechenov University); Yaroslavl State University

Email: almaz_305@mail.ru

Ph.D. (Psych.), Leading Research Scientist, Laboratory of Molecular Nutrition, Center for Bielementology and Human Ecology, Research Scientist, Laboratory of Ecobiomonitoring and Quality Control

Russian Federation, Moscow; Yaroslavl

A. A. Tinkov

Yaroslavl State University; Peoples Friendship University of Russia (RUDN University); I.M. Sechenov First Moscow State Medical University (Sechenov University)

Email: tinkov.a.a@gmail.com

Dr.Sc. (Med.), Head of Laboratory of Ecobiomonitoring and Quality Control, Associate Professor of the Department of Medical Elementology, Leading Research Scientist, Laboratory of Molecular Nutrition, Center for Bielementology and Human Ecology

Russian Federation, Yaroslavl; Moscow; Moscow

A. V. Skalny

Yaroslavl State University; I.M. Sechenov First Moscow State Medical University (Sechenov University); Peoples Friendship University of Russia (RUDN University)

Email: skalny3@microelements.ru

Dr.Sc. (Med.), Professor, Leading Research Scientist, Laboratory of Ecobiomonitoring and Quality Control, Director of the Center for Bielementology and Human Ecology, Head of Department of Medical Elementology

Russian Federation, Yaroslavl; Moscow; Moscow

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